Laboratory of Personality and Cognition, National Institute on Aging, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA.
Cereb Cortex. 2009 Dec;19(12):2797-802. doi: 10.1093/cercor/bhp066. Epub 2009 Apr 14.
We investigated sex differences in the resting-state neural correlates of Openness to Experience, a universal personality trait defined by cognitive flexibility, attention to feelings, creativity, and preference for novelty. Using resting-state positron-emission tomography from 100 older individuals (>55 years of age), we identified associations between Openness and resting-state regional cerebral blood flow that replicated across 2 assessments of the same sample, approximately 2 years apart. Openness correlated positively with prefrontal activity in women, anterior cingulate activity in men, and orbitofrontal activity in both sexes, which suggests that areas linked to cognitive flexibility (women), monitoring processes (men), and reward and emotional processing (both) underlie individual differences in Openness. The results challenge the implicit assumption that the same trait will rely on the same neural mechanisms across all who express it.
我们研究了开放性人格特质在静息状态下的神经相关性在性别上的差异，开放性是一种普遍的人格特质，由认知灵活性、关注感受、创造力和对新奇事物的偏好定义。我们使用来自 100 名老年人（>55 岁）的静息状态正电子发射断层扫描（PET），确定了开放性与静息状态局部脑血流之间的关联，这些关联在对同一样本的两次评估中得到了复制，两次评估大约相隔两年。开放性与女性的前额叶活动、男性的前扣带回活动以及两性的眶额皮层活动呈正相关，这表明与认知灵活性（女性）、监测过程（男性）和奖励和情绪处理（两性）相关的区域是开放性个体差异的基础。这些结果挑战了一个隐含的假设，即相同的特质在所有表现出该特质的人中都将依赖于相同的神经机制。
