Sohn Dong Wan, Han Chang Hee, Jung Yun Seok, Kim Sung In, Kim Sae Woong, Cho Yong-Hyun
Department of Urology, College of Medicine, The Catholic University of Korea, St Mary's Hospital, 62 Youido-dong, Youngdungpoku, Seoul 150-713, South Korea.
Int J Antimicrob Agents. 2009 Sep;34(3):215-9. doi: 10.1016/j.ijantimicag.2009.02.012. Epub 2009 Apr 17.
Chronic bacterial prostatitis (CBP), which is characterised by recurrent urinary tract infection (UTI) and persistence of pathogenic bacteria and evidence of inflammation in the prostatic secretions, is one of the most common causes of relapsing UTI in men. In this study, we evaluated the antimicrobial and anti-inflammatory effects of garlic as well as the synergistic effect of garlic with ciprofloxacin on the treatment of CBP in an animal model. An experimental CBP model was induced in 60 adult male Sprague-Dawley rats by instillation of 0.2 mL of bacterial suspension (Escherichia coli Z17, O2:K1:H-) containing 1 x 10(8) colony-forming units/mL into the prostatic urethra. Microbiologically and histologically proven CBP was demonstrated in 68.3% (41/60) of the rats after 4 weeks of bacterial instillation. The 41 rats demonstrating CBP were randomly divided into four treatment groups: control; garlic; ciprofloxacin; and garlic plus ciprofloxacin. After 3 weeks of treatment, microbiological cultures of the urine and prostate samples as well as histological findings of the prostate were analysed. Microbiological cultures and histological findings of the prostate samples demonstrated reduced bacterial growth and improved inflammatory responses in all three experimental groups compared with the control group. The garlic group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the control group. The garlic plus ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the ciprofloxacin group. These results suggest that garlic may have anti-inflammatory and antimicrobial effects as well as a synergistic effect with ciprofloxacin. We therefore suggest that the combination of garlic and ciprofloxacin may be effective in treating CBP with a higher success rate.
慢性细菌性前列腺炎（CBP）的特征是反复出现尿路感染（UTI）、病原菌持续存在以及前列腺分泌物中有炎症迹象，是男性复发性UTI的最常见原因之一。在本研究中，我们在动物模型中评估了大蒜的抗菌和抗炎作用以及大蒜与环丙沙星联合治疗CBP的协同作用。通过向前列腺尿道注入0.2 mL含1×10⁸ 菌落形成单位/ mL的细菌悬液（大肠杆菌Z17，O2:K1:H-），在60只成年雄性Sprague-Dawley大鼠中诱导建立实验性CBP模型。细菌注入4周后，68.3%（41/60）的大鼠经微生物学和组织学证实患有CBP。将这41只患有CBP的大鼠随机分为四个治疗组：对照组；大蒜组；环丙沙星组；大蒜加环丙沙星组。治疗3周后，分析尿液和前列腺样本的微生物培养结果以及前列腺的组织学 findings。与对照组相比，所有三个实验组的前列腺样本微生物培养结果和组织学 findings均显示细菌生长减少，炎症反应改善。与对照组相比，大蒜组细菌生长有统计学意义的下降，前列腺炎症有所改善。与环丙沙星组相比，大蒜加环丙沙星组细菌生长有统计学意义的下降，前列腺炎症有所改善。这些结果表明，大蒜可能具有抗炎和抗菌作用以及与环丙沙星的协同作用。因此，我们认为大蒜和环丙沙星联合使用可能有效治疗CBP，成功率更高。
