Department of Urology, St. Paul Hospital, The Catholic University of Korea College of Medicine, Suwon, Korea.
J Infect Chemother. 2012 Feb;18(1):30-4. doi: 10.1007/s10156-011-0276-4. Epub 2011 Aug 4.
The antibiotic treatment rate of chronic bacterial prostatitis (CBP) is low, and long-term administration can result in adverse events and bacterial resistance. For these reasons, a new preventive modality, which can replace traditional antibiotic therapy, is required. To evaluate the preventive effect of selenium on CBP, the pre-treatments were divided into four groups, administered for 4 weeks, as follows: (1) control, (2) ciprofloxacin, (3) selenium, and (4) ciprofloxacin and selenium. Then, drip infusion of a bacterial suspension (Escherichia coli Z17, O2:K1; H-) into the prostatic urethra of Wistar rats was conducted to induce CBP. In 4 weeks, the results of microbiological culture of prostate and urine samples as well as histological findings of the prostate in each group were analyzed. Selenium decreased bacterial infection significantly; the decrease in infiltration rate of inflammatory cells into prostate tissues in the selenium group was similar to that in the control group. The effect of hindering bacterial infection on prostate tissue was greater in the group administered both selenium and an antibiotic than in other groups given only one of the agents. Although the findings of this study suggest that selenium can have a preventive effect against the occurrence of CBP, methods to prevent CBP are still controversial.
慢性细菌性前列腺炎（CBP）的抗生素治疗率较低，长期应用会导致不良反应和细菌耐药。因此，需要一种新的预防方法来替代传统的抗生素治疗。为了评估硒对 CBP 的预防作用，将预处理分为四组，连续给药 4 周，具体如下：（1）对照组，（2）环丙沙星组，（3）硒组，和（4）环丙沙星和硒组。然后，将细菌悬浮液（大肠杆菌 Z17、O2:K1；H-）滴注到 Wistar 大鼠的前列腺尿道中，以诱导 CBP。4 周后，分析每组前列腺和尿液样本的微生物培养以及前列腺组织的组织学发现。硒显著降低了细菌感染；硒组前列腺组织中炎性细胞浸润率的降低与对照组相似。与仅给予一种药物的其他组相比，同时给予硒和抗生素的组对前列腺组织的细菌感染抑制作用更大。尽管本研究结果表明硒对 CBP 的发生具有预防作用，但预防 CBP 的方法仍存在争议。
