Department of Urology, St Mary's Hospital, The Catholic University of Korea College of Medicine, 62 Youido-dong, Youngdungpoku, Seoul, 150-713, Korea.
J Infect Chemother. 2011 Apr;17(2):189-94. doi: 10.1007/s10156-010-0098-9. Epub 2010 Aug 7.
Chronic bacterial prostatitis (CBP) is one of the most common relapsing urinary tract infection (UTI) in males. Catechin, an extract of green tea, is known to have anti-inflammatory and antimicrobial effects against various bacteria. However, catechin can be easily degenerated during digestion, and this may result in decreased absorption into the body. Nanocatechin is catechin coated with hydroxypropyl methyl cellulose by nanotechnology. It reduces degeneration during digestion and enhances absorption of catechin into the body. We evaluated the anti-inflammatory and antimicrobial effect of nanocatechin on CBP and also analyzed plasma concentration of catechins to evaluate absorptivity in an animal model. Forty rats demonstrating CBP were randomly divided into four groups: control, ciprofloxacin, catechin, and nanocatechin. After treatment, the results of microbiological culture of prostate and urine samples as well as histological findings of the prostate in each group were analyzed. Plasma concentration of catechins in catechin and nanocatechin groups was compared. The use of ciprofloxacin, catechin, and nanocatechin showed statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the control group. The nanocatechin group showed statistically significant decrease in bacterial growth and improvement in prostatic inflammation compared with the catechin group. Plasma concentrations of epicatechin, gallocatechin gallate, and epigallocatechin gallate were significantly higher in the nanocatechin group than those in the catechin group. These results suggest that nanocatechin has better antimicrobial and anti-inflammatory effects on rat CBP than catechin due to higher absorption into the body.
慢性细菌性前列腺炎（CBP）是男性最常见的复发性尿路感染（UTI）之一。儿茶素是绿茶的提取物，具有抗炎和抗多种细菌的作用。然而，儿茶素在消化过程中很容易降解，这可能导致其在体内的吸收减少。纳米儿茶素是通过纳米技术将儿茶素与羟丙基甲基纤维素包裹而成的。它可以减少在消化过程中的降解，增强儿茶素在体内的吸收。我们评估了纳米儿茶素对 CBP 的抗炎和抗菌作用，并分析了血浆中儿茶素浓度，以评估其在动物模型中的吸收能力。40 只患有 CBP 的大鼠被随机分为四组：对照组、环丙沙星组、儿茶素组和纳米儿茶素组。治疗后，分析各组前列腺和尿液样本的微生物培养结果以及前列腺的组织学发现。比较了儿茶素组和纳米儿茶素组的血浆儿茶素浓度。与对照组相比，环丙沙星、儿茶素和纳米儿茶素的使用均显示出细菌生长的统计学显著减少和前列腺炎症的改善。与儿茶素组相比，纳米儿茶素组的细菌生长减少和前列腺炎症改善更为显著。与儿茶素组相比，纳米儿茶素组的表儿茶素、没食子儿茶素没食子酸酯和表没食子儿茶素没食子酸酯的血浆浓度显著升高。这些结果表明，纳米儿茶素对大鼠 CBP 的抗菌和抗炎作用优于儿茶素，因为它在体内的吸收更高。
