Chang Pamela V, Chen Xing, Smyrniotis Chris, Xenakis Alexander, Hu Tianshun, Bertozzi Carolyn R, Wu Peng
Department of Chemistry and Howard Hughes Medical Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Angew Chem Int Ed Engl. 2009;48(22):4030-3. doi: 10.1002/anie.200806319.
Sialome sweet sialome: As sialic acids are involved in many host-pathogen recognition events and are markers of embryonic and malignant tissues, there is great interest in methods for the enrichment and identification of sialylated glycoproteins from complex tissues. Now N-(4-pentynoyl)mannosamine can be used to metabolically label sialylated glycoproteins in living animals, enabling future identification of new biomarkers.
由于唾液酸参与许多宿主-病原体识别事件，并且是胚胎组织和恶性组织的标志物，因此人们对从复杂组织中富集和鉴定唾液酸化糖蛋白的方法非常感兴趣。现在，N-（4-戊炔酰基）甘露糖胺可用于在活体动物中对唾液酸化糖蛋白进行代谢标记，从而有助于未来鉴定新的生物标志物。
