美国水鼩鼱（Neurotrichus gibbsii）中一种基因独特的汉坦病毒进化过程中的宿主转换
Host switch during evolution of a genetically distinct hantavirus in the American shrew mole (Neurotrichus gibbsii).
作者信息
Kang Hae Ji, Bennett Shannon N, Dizney Laurie, Sumibcay Laarni, Arai Satoru, Ruedas Luis A, Song Jin-Won, Yanagihara Richard
机构信息
Pacific Center for Emerging Infectious Diseases Research, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI 96813, USA.
出版信息
Virology. 2009 May 25;388(1):8-14. doi: 10.1016/j.virol.2009.03.019. Epub 2009 Apr 23.
A genetically distinct hantavirus, designated Oxbow virus (OXBV), was detected in tissues of an American shrew mole (Neurotrichus gibbsii), captured in Gresham, Oregon, in September 2003. Pairwise analysis of full-length S- and M- and partial L-segment nucleotide and amino acid sequences of OXBV indicated low sequence similarity with rodent-borne hantaviruses. Phylogenetic analyses using maximum-likelihood and Bayesian methods, and host-parasite evolutionary comparisons, showed that OXBV and Asama virus, a hantavirus recently identified from the Japanese shrew mole (Urotrichus talpoides), were related to soricine shrew-borne hantaviruses from North America and Eurasia, respectively, suggesting parallel evolution associated with cross-species transmission.
2003年9月在俄勒冈州格雷沙姆捕获的一只美洲鼩鼱（Neurotrichus gibbsii）的组织中，检测到一种基因上不同的汉坦病毒，命名为奥克斯博病毒（OXBV）。对奥克斯博病毒全长S、M片段以及部分L片段的核苷酸和氨基酸序列进行成对分析表明，其与啮齿动物传播的汉坦病毒的序列相似性较低。使用最大似然法和贝叶斯方法进行的系统发育分析以及宿主-寄生虫进化比较显示，奥克斯博病毒和最近从日本鼩鼱（Urotrichus talpoides）中鉴定出的汉坦病毒浅间病毒，分别与来自北美和欧亚大陆的鼩鼱传播的汉坦病毒相关，这表明与跨物种传播相关的平行进化。
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