西维斯病毒，一种在欧亚普通鼩鼱（Sorex araneus）中基因独特的汉坦病毒。
Seewis virus, a genetically distinct hantavirus in the Eurasian common shrew (Sorex araneus).
作者信息
Song Jin-Won, Gu Se Hun, Bennett Shannon N, Arai Satoru, Puorger Maria, Hilbe Monika, Yanagihara Richard
机构信息
Department of Microbiology, College of Medicine, and Institute for Viral Diseases, Korea University, 5-ga, Anam-dong, Sungbuk-gu, Seoul 136-705, Korea.
出版信息
Virol J. 2007 Oct 30;4:114. doi: 10.1186/1743-422X-4-114.
More than 20 years ago, hantaviral antigens were reported in tissues of the Eurasian common shrew (Sorex araneus), Eurasian water shrew (Neomys fodiens) and common mole (Talpa europea), suggesting that insectivores, or soricomorphs, might serve as reservoirs of unique hantaviruses. Using RT-PCR, sequences of a genetically distinct hantavirus, designated Seewis virus (SWSV), were amplified from lung tissue of a Eurasian common shrew, captured in October 2006 in Graubünden, Switzerland. Pair-wise analysis of the full-length S and partial M and L segments of SWSV indicated approximately 55%-72% similarity with hantaviruses harbored by Murinae, Arvicolinae, Neotominae and Sigmodontinae rodents. Phylogenetically, SWSV grouped with other recently identified shrew-borne hantaviruses. Intensified efforts are underway to clarify the genetic diversity of SWSV throughout the geographic range of the Eurasian common shrew, as well as to determine its relevance to human health.
20多年前，在欧亚普通鼩鼱（Sorex araneus）、欧亚水鼩鼱（Neomys fodiens）和普通鼹鼠（Talpa europea）的组织中发现了汉坦病毒抗原，这表明食虫目动物或鼩形目动物可能是独特汉坦病毒的宿主。通过逆转录聚合酶链反应（RT-PCR），从2006年10月在瑞士格劳宾登捕获的一只欧亚普通鼩鼱的肺组织中扩增出一种基因独特的汉坦病毒——西维斯病毒（SWSV）的序列。对SWSV全长S基因以及部分M和L基因片段进行的成对分析表明，它与鼠亚科、田鼠亚科、林鼠亚科和稻鼠亚科啮齿动物携带的汉坦病毒具有约55%-72%的相似性。在系统发育上，SWSV与其他最近发现的由鼩鼱传播的汉坦病毒归为一类。目前正在加大力度，以阐明SWSV在欧亚普通鼩鼱整个地理分布范围内的遗传多样性，并确定其与人类健康的相关性。
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