Kim Won-Serk, Park Byung-Soon, Sung Jong-Hyuk
Department of Dermatology, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, Korea.
Arch Dermatol Res. 2009 Jun;301(5):329-36. doi: 10.1007/s00403-009-0951-9. Epub 2009 Apr 26.
As individuals age, the skin undergoes changes, such as irregular pigmentation, thinning and loss of elasticity, that are due to both genetic and environmental factors. These changes may worsen, progressing to precancerous and cancerous diseases. Various medical treatments and topical cosmeceuticals have been used to treat some symptoms of photoaging, however, the results have been less than satisfactory. Mesenchymal stem cells within the stromal-vascular fraction of subcutaneous adipose tissue, adipose-derived stem cells (ADSCs), display multi-lineage developmental plasticity and secrete various growth factors that control and manage the damaged neighboring cells. Recently, the production and secretion of growth factors has been reported as an essential function of ADSCs, and diverse regenerative effects of ADSCs have been demonstrated in the skin. For example, conditioned medium from ADSCs (ADSC-CM) stimulated both collagen synthesis and migration of dermal fibroblasts, which improved the wrinkling and accelerated wound healing in animal models. ADSC-CM also inhibited melanogenesis in B16 melanoma cells, and protected dermal fibroblasts from oxidative stress induced by chemicals and UVB irradiation. Therefore, ADSCs and soluble factors show promise for the treatment of photoaging, and this review introduces recent research developments of the ADSCs and ADSC-derived secretory factors regarding this issue.
随着个体年龄的增长，皮肤会发生变化，如色素沉着不均、变薄和弹性丧失，这些变化是由遗传和环境因素共同导致的。这些变化可能会恶化，发展为癌前疾病和癌症。各种医学治疗方法和局部美容化妆品已被用于治疗光老化的一些症状，然而，效果并不理想。皮下脂肪组织的基质血管成分中的间充质干细胞，即脂肪来源干细胞（ADSCs），具有多谱系发育可塑性，并分泌各种生长因子来控制和管理受损的邻近细胞。最近，生长因子的产生和分泌已被报道为ADSCs的一项重要功能，并且ADSCs在皮肤中已显示出多种再生作用。例如，ADSCs的条件培养基（ADSC-CM）刺激了真皮成纤维细胞的胶原蛋白合成和迁移，这改善了动物模型中的皱纹并加速了伤口愈合。ADSC-CM还抑制了B16黑色素瘤细胞中的黑色素生成，并保护真皮成纤维细胞免受化学物质和紫外线B照射诱导的氧化应激。因此，ADSCs和可溶性因子在光老化治疗方面显示出前景，本综述介绍了关于此问题的ADSCs和ADSC衍生分泌因子的最新研究进展。
