Bagge E, Bjelle A, Edén S, Svanborg A
Department of Rheumatology, University of Göteborg, Sweden.
J Rheumatol. 1991 Aug;18(8):1218-22.
Selected factors potentially associated with radiographic osteoarthritis (OA) were studied in 2 subsamples of 79-year-olds, within the longitudinal prospective study 70-year-old People in Göteborg. A very significant (p less than 0.01 in men, p less than 0.001 in women) association was found between radiographic knee OA and body mass index (BMI), and a significant (p less than 0.05) association was also observed between radiographic hand OA and BMI in men. Smoking correlated negatively (p less than 0.01) to radiographic knee OA in both sexes, even after adjusting for BMI. Other factors, including diabetes, ischemic heart disease, hypertension, physical activity, education, vocational training, marital status, serum uric acid, triglycerides, cholesterol and blood glucose levels did not correlate to radiographic OA. Finally, no correlation was found between either decreased bone mineral content or the presence of previous fragility fractures.
在哥德堡70岁人群纵向前瞻性研究中，对两个79岁的子样本进行了研究，探讨了与放射学骨关节炎（OA）潜在相关的因素。研究发现，放射学膝关节OA与体重指数（BMI）之间存在非常显著的关联（男性p<0.01，女性p<0.001），男性中放射学手部OA与BMI之间也存在显著关联（p<0.05）。即使在调整BMI后，吸烟与两性的放射学膝关节OA均呈负相关（p<0.01）。其他因素，包括糖尿病、缺血性心脏病、高血压、身体活动、教育程度、职业培训、婚姻状况、血清尿酸、甘油三酯、胆固醇和血糖水平，与放射学OA均无相关性。最后，骨矿物质含量降低或既往脆性骨折的存在之间均未发现相关性。
