North West Lung Research Centre, University of Manchester, South Manchester University Hospitals Trust, Wythenshawe, Manchester, UK.
Int J Chron Obstruct Pulmon Dis. 2009;4:149-56. doi: 10.2147/copd.s5018. Epub 2009 Apr 15.
Many of the systemic manifestations of chronic obstructive pulmonary disease (COPD) are mediated through increased systemic levels of inflammatory proteins. We assessed the long term repeatability of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP) over one year and examined the relationships between these systemic markers in COPD.
Fifty-eight stable COPD patients completed a baseline and one-year visit. Serum IL-6, plasma CRP, and plasma TNF-alpha were measured. Repeatability was expressed by intraclass correlation coefficient (R(i)) and the Bland-Altman method. Pearson correlations were used to determine the relationships between the systemic markers at both visits.
There was moderate repeatability with a very high degree of statistical significance (p <or= 0.001) between the two visits for all the systemic biomarkers (IL-6, CRP, and TNF-alpha). CRP was significantly associated with IL-6 at both visits (r = 0.55, p = 0.0001, r = 0.51, p = 0.0002, respectively). There were no other significant associations between the systemic markers at either of the visits.
Systemic inflammatory biomarkers IL-6, CRP, and TNF-alpha were moderately repeatable over a twelve month period in COPD patients. We have also shown that a robust and repeatable association between IL-6 and CRP exists.
慢性阻塞性肺疾病（COPD）的许多全身表现是通过增加全身炎症蛋白水平来介导的。我们评估了白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）和 C 反应蛋白（CRP）在一年中的长期可重复性，并检查了 COPD 中这些全身标志物之间的关系。
58 例稳定期 COPD 患者完成了基线和一年期就诊。测量血清 IL-6、血浆 CRP 和血浆 TNF-α。用组内相关系数（R(i)）和 Bland-Altman 法表示重复性。Pearson 相关用于确定两次就诊时全身标志物之间的关系。
所有全身生物标志物（IL-6、CRP 和 TNF-α）在两次就诊之间均具有中度重复性，具有非常高的统计学意义（p <or= 0.001）。CRP 在两次就诊时均与 IL-6 显著相关（r = 0.55，p = 0.0001，r = 0.51，p = 0.0002）。在两次就诊时，全身标志物之间没有其他显著相关性。
COPD 患者全身炎症生物标志物 IL-6、CRP 和 TNF-α在 12 个月期间具有中度可重复性。我们还表明，IL-6 和 CRP 之间存在强大且可重复的关联。
