Tsui Ivy F L, Chari Raj, Buys Timon P H, Lam Wan L
Cancer Genetics and Developmental Biology, British Columbia Cancer Research Centre, and Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.
Cancer Inform. 2007 Dec 12;3:379-97.
The study of pathway disruption is key to understanding cancer biology. Advances in high throughput technologies have led to the rapid accumulation of genomic data. The explosion in available data has generated opportunities for investigation of concerted changes that disrupt biological functions, this in turns created a need for computational tools for pathway analysis. In this review, we discuss approaches to the analysis of genomic data and describe the publicly available resources for studying biological pathways.
通路破坏的研究是理解癌症生物学的关键。高通量技术的进步导致了基因组数据的快速积累。可用数据的激增为研究破坏生物学功能的协同变化创造了机会，这反过来又产生了对通路分析计算工具的需求。在本综述中，我们讨论了基因组数据分析方法，并描述了用于研究生物通路的公开可用资源。
