Han D-O, Lee H-J, Hahm D-H
Acupuncture & Meridian Science Research Center, Kyung-Hee University, Hoigi-dong, Dongdaemoon-gu, Seoul, Korea.
Methods Find Exp Clin Pharmacol. 2009 Mar;31(2):95-100. doi: 10.1358/mf.2009.31.2.1353846.
Inhibition of inflammatory responses, acceleration of basal cell growth and balanced synthesis of the extracellular matrix (ECM) are important in the healing of open cutaneous wounds. To evaluate the wound-healing effects of Astragali Radix (AR) (the root of Astragalus membranaceus [Fisch.]), experimental open wounds were made on the dorsal side of rats under anesthesia. Boiling water extracts of AR, soaked into a hydrophilic foam dressing, were topically applied to the wounds once a day for 11 consecutive days. The healing process was assessed by scoring macroscopic appearance and measuring the area of the open wounds. Molecular aspects of the healing skin area were also investigated via histological observation indicating cell density and linear alignment of the granulation tissue. The AR extracts significantly accelerated cutaneous wound healing by suppressing inflammation and stimulating basal cell growth in the wound area compared to epidermal growth factor as a positive control. Promotion of basal cell proliferation and angiogenesis by the AR extracts was remarkable in the early stages of wound healing, resulting in a significant reduction in the duration of the wound-healing process. We conclude that extracts of AR could be useful in enhancing cutaneous wound healing.
抑制炎症反应、加速基底细胞生长以及平衡细胞外基质（ECM）的合成，对于开放性皮肤伤口的愈合至关重要。为了评估黄芪（AR）（蒙古黄芪[豆科]的根）的伤口愈合效果，在麻醉状态下于大鼠背部制造实验性开放性伤口。将AR的沸水提取物浸泡在亲水性泡沫敷料中，每天一次局部应用于伤口，连续11天。通过对宏观外观评分和测量开放性伤口面积来评估愈合过程。还通过组织学观察研究愈合皮肤区域的分子层面，观察指标包括细胞密度和肉芽组织的线性排列。与作为阳性对照的表皮生长因子相比，AR提取物通过抑制炎症和刺激伤口区域的基底细胞生长，显著加速了皮肤伤口愈合。在伤口愈合早期，AR提取物对基底细胞增殖和血管生成的促进作用显著，从而显著缩短了伤口愈合过程的持续时间。我们得出结论，AR提取物可能有助于促进皮肤伤口愈合。
