Department of Pharmacology, Chung Shan Medical University, Taichung 40201, Taiwan, R.O.C.
Division of Animal Medicine, Animal Technology Laboratories, Agricultural Technology Research Institute, Miaoli 35053, Taiwan, R.O.C.
Mol Med Rep. 2018 Jun;17(6):8047-8052. doi: 10.3892/mmr.2018.8917. Epub 2018 Apr 23.
Minoxidil and finasteride have been approved to treat hair loss by the Food and Drug Administration. However, the further elucidation of treatments for hair loss, including those using Chinese herbal medicine, remains important clinically. BeauTop (BT) is a health food supplement which contains Ginseng radix, Astragali radix, Radix Angelicae sinensis, Ligustri fructus, Rehmannia glutinosa and Eclipta prostrata (Linn). Susbsequent to oral administration of BT at 0.6 g/kg/day to wax/rosin‑induced alopecia in C57BL/6 mice, BT significantly induced hair growth at day 8 compared with control treatment (P<0.05). The expression levels of epidermal growth factor (EGF), and fibroblast growth factor (FGF)‑7 were increased compared with control animals on day 8. In contrast, levels of FGF‑5 of the BT group were reduced compared with the control on day 12. There were no effects on the expression of insulin‑like growth factor 1. The results demonstrated that the mechanism of BT improving alopecia is potentially associated with modulation of EGF and FGF‑7 levels. Taken together, it is suggested that BT may have a potential effect of the promotion of hair growth.
米诺地尔和非那雄胺已被美国食品和药物管理局批准用于治疗脱发。然而，进一步阐明脱发的治疗方法，包括使用中药，在临床上仍然很重要。BeauTop（BT）是一种含有人参、黄芪、当归、川芎、熟地和旱莲草的保健品。BT 以 0.6 g/kg/天的剂量口服给药，可显著促进蜡/松香诱导的 C57BL/6 小鼠脱发模型的毛发生长，与对照组相比，BT 在第 8 天的毛发生长明显增加（P<0.05）。与对照组相比，BT 组在第 8 天表皮生长因子（EGF）和纤维母细胞生长因子（FGF）-7 的表达水平增加。相反，在第 12 天，BT 组的 FGF-5 水平与对照组相比降低。胰岛素样生长因子 1 的表达不受影响。结果表明，BT 改善脱发的机制可能与调节 EGF 和 FGF-7 水平有关。综上所述，BT 可能具有促进头发生长的潜在作用。
