人类对甲型H5N1流感病毒感染的抗体反应动力学及持久性
Kinetics and longevity of antibody response to influenza A H5N1 virus infection in humans.
作者信息
Kitphati Rungrueng, Pooruk Phisanu, Lerdsamran Hatairat, Poosuwan Siriwan, Louisirirotchanakul Suda, Auewarakul Prasert, Chokphaibulkit Kulkanya, Noisumdaeng Pirom, Sawanpanyalert Pathom, Puthavathana Pilaipan
机构信息
National Institute of Health, Department of Medical Sciences, Ministry of Public Health, Nonthaburi, Thailand.
出版信息
Clin Vaccine Immunol. 2009 Jul;16(7):978-81. doi: 10.1128/CVI.00062-09. Epub 2009 May 20.
Abstract
Anti-H5N1 antibody was determined by microneutralization, hemagglutination inhibition, and Western blotting assays in serial blood samples collected from eight Thai patients, including four fatal cases and four survivors. The antibody was detected as early as 5 days and, typically, with an increase in titer in paired blood at about 15 days after disease onset. The anti-H5 antibody response was long-lasting, for almost 5 years in cases which can be followed that far. In addition, cross-neutralizing activity to related clade 1 viruses was observed.
摘要
通过微量中和试验、血凝抑制试验和蛋白质印迹分析，对从8名泰国患者（包括4例死亡病例和4例幸存者）采集的系列血样中的抗H5N1抗体进行了检测。抗体最早在发病后5天即可检测到，通常在发病后约15天配对血样中的抗体滴度会升高。抗H5抗体反应具有持久性，在可随访到的病例中，这种反应可持续近5年。此外，还观察到对相关1类分支病毒的交叉中和活性。
相似文献
1
Kinetics and longevity of antibody response to influenza A H5N1 virus infection in humans.
Clin Vaccine Immunol. 2009 Jul;16(7):978-81. doi: 10.1128/CVI.00062-09. Epub 2009 May 20.
2
Kinetics, Longevity, and Cross-Reactivity of Antineuraminidase Antibody after Natural Infection with Influenza A Viruses.
Clin Vaccine Immunol. 2017 Dec 5;24(12). doi: 10.1128/CVI.00248-17. Print 2017 Dec.
3
Induction of cross-neutralizing antibody against H5N1 virus after vaccination with seasonal influenza vaccine in COPD patients.
Viral Immunol. 2010 Jun;23(3):329-34. doi: 10.1089/vim.2009.0082.
4
Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses.
Vaccine. 2009 Oct 9;27(43):5998-6003. doi: 10.1016/j.vaccine.2009.07.079. Epub 2009 Aug 7.
5
Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays.
J Clin Microbiol. 1999 Apr;37(4):937-43. doi: 10.1128/JCM.37.4.937-943.1999.
6
A sensitive retroviral pseudotype assay for influenza H5N1-neutralizing antibodies.
Influenza Other Respir Viruses. 2007 May;1(3):105-12. doi: 10.1111/j.1750-2659.2007.00016.x.
7
A novel humanized antibody neutralizes H5N1 influenza virus via two different mechanisms.
J Virol. 2015 Apr;89(7):3712-22. doi: 10.1128/JVI.03014-14. Epub 2015 Jan 21.
8
Cross-reactive immunity against influenza viruses in children and adults following 2009 pandemic H1N1 infection.
Antiviral Res. 2015 Feb;114:106-12. doi: 10.1016/j.antiviral.2014.12.008. Epub 2014 Dec 13.
9
Neutralizing antibody but not hemagglutination antibody provides accurate evaluation for protective immune response to H5N1 avian influenza virus in vaccinated rabbits.
Vaccine. 2011 Jul 26;29(33):5421-3. doi: 10.1016/j.vaccine.2011.05.067. Epub 2011 Jun 7.
10
Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts.
J Infect Dis. 1999 Dec;180(6):1763-70. doi: 10.1086/315137.
引用本文的文献
1
Delay of innate immune responses following influenza B virus infection affects the development of a robust antibody response in ferrets.
mBio. 2025 Feb 5;16(2):e0236124. doi: 10.1128/mbio.02361-24. Epub 2025 Jan 8.
2
On the Evolutionary Trajectory of SARS-CoV-2: Host Immunity as a Driver of Adaptation in RNA Viruses.
Viruses. 2022 Dec 26;15(1):70. doi: 10.3390/v15010070.
3
Serologic Evidence of Occupational Exposure to Avian Influenza Viruses at the Wildfowl/Poultry/Human Interface.
Microorganisms. 2021 Oct 15;9(10):2153. doi: 10.3390/microorganisms9102153.
4
T cell mediated immunity against influenza H5N1 nucleoprotein, matrix and hemagglutinin derived epitopes in H5N1 survivors and non-H5N1 subjects.
PeerJ. 2021 Mar 10;9:e11021. doi: 10.7717/peerj.11021. eCollection 2021.
5
Persistence of H7N9 virus antibody response 2 years after infection.
Influenza Other Respir Viruses. 2020 Mar;14(2):210-214. doi: 10.1111/irv.12702. Epub 2019 Dec 19.
6
Novel Avian Influenza A Virus Infections of Humans.
Infect Dis Clin North Am. 2019 Dec;33(4):907-932. doi: 10.1016/j.idc.2019.07.003.
7
Characterization of antibody and memory T-cell response in H7N9 survivors: a cross-sectional analysis.
Clin Microbiol Infect. 2020 Feb;26(2):247-254. doi: 10.1016/j.cmi.2019.06.013. Epub 2019 Jun 20.
8
Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection.
Nat Commun. 2018 Aug 20;9(1):3328. doi: 10.1038/s41467-018-05746-9.
9
The Effects of Birth Year, Age and Sex on Hemagglutination Inhibition Antibody Responses to Influenza Vaccination.
Vaccines (Basel). 2018 Jul 3;6(3):39. doi: 10.3390/vaccines6030039.
10
Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017.
Emerg Infect Dis. 2018 Apr;24(4):663-672. doi: 10.3201/eid2404.171995. Epub 2018 Apr 17.
本文引用的文献
1
Seroprevalence of antibodies to avian influenza virus A (H5N1) among residents of villages with human cases, Thailand, 2005.
Emerg Infect Dis. 2009 May;15(5):756-60. doi: 10.3201/eid1505.080316.
2
Update on avian influenza A (H5N1) virus infection in humans.
N Engl J Med. 2008 Jan 17;358(3):261-73. doi: 10.1056/NEJMra0707279.
3
An avian influenza H5N1 virus that binds to a human-type receptor.
J Virol. 2007 Sep;81(18):9950-5. doi: 10.1128/JVI.00468-07. Epub 2007 Jul 11.
4
Erythrocyte binding preference of avian influenza H5N1 viruses.
J Clin Microbiol. 2007 Jul;45(7):2284-6. doi: 10.1128/JCM.00921-07. Epub 2007 May 23.
5
Three Indonesian clusters of H5N1 virus infection in 2005.
N Engl J Med. 2006 Nov 23;355(21):2186-94. doi: 10.1056/NEJMoa060930.
6
Probable person-to-person transmission of avian influenza A (H5N1).
N Engl J Med. 2005 Jan 27;352(4):333-40. doi: 10.1056/NEJMoa044021. Epub 2005 Jan 24.
7
Molecular characterization of the complete genome of human influenza H5N1 virus isolates from Thailand.
J Gen Virol. 2005 Feb;86(Pt 2):423-433. doi: 10.1099/vir.0.80368-0.
8
Sialic acid receptor specificity on erythrocytes affects detection of antibody to avian influenza haemagglutinin.
J Med Virol. 2003 Jul;70(3):391-8. doi: 10.1002/jmv.10408.
9
Antibody response in individuals infected with avian influenza A (H5N1) viruses and detection of anti-H5 antibody among household and social contacts.
J Infect Dis. 1999 Dec;180(6):1763-70. doi: 10.1086/315137.
10
Detection of antibody to avian influenza A (H5N1) virus in human serum by using a combination of serologic assays.
J Clin Microbiol. 1999 Apr;37(4):937-43. doi: 10.1128/JCM.37.4.937-943.1999.
Zotero 插件