雷帕霉素通过自噬延长酵母的程序性寿命。
Autophagy is required for extension of yeast chronological life span by rapamycin.
机构信息
Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.
出版信息
Autophagy. 2009 Aug;5(6):847-9. doi: 10.4161/auto.8824. Epub 2009 Aug 23.
Abstract
Rapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes, including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin extend yeast chronological life span (CLS). We have recently shown that autophagy is required for chronological longevity in yeast, which is attributable in part to a role for autophagy in amino acid homeostasis. We report herein that low concentrations of rapamycin stimulate macroautophagy during chronological aging and extend CLS.
摘要
雷帕霉素是一种抗生素，可刺激多种真核生物（包括芽殖酵母酿酒酵母）的自噬。低浓度的雷帕霉素可延长酵母的时效寿命（CLS）。我们最近表明，自噬对于酵母的时效寿命是必需的，这部分归因于自噬在氨基酸稳态中的作用。我们在此报告，低浓度的雷帕霉素在酵母的时效老化过程中刺激巨自噬，并延长 CLS。
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