Jokinen Janne J, Turpeinen Anu K, Pitkänen Otto, Hippeläinen Mikko J, Hartikainen Juha E K
Department of Cardiothoracic Surgery, Helsinki University Hospital, Helsinki, Finland.
Ann Thorac Surg. 2009 Jun;87(6):1806-14. doi: 10.1016/j.athoracsur.2009.03.048.
We studied the incidence and predictors of permanent pacemaker implantation after tricuspid valve operation and its implications on patient outcome in terms of survival, morbidity, and quality of life.
Between 1992 and 2007, 136 consecutive patients underwent tricuspid valve repair or valve replacement with a biologic valve at Kuopio University Hospital. Comprehensive clinical data were recorded prospectively. Data for the Nottingham Health Profile quality of life analysis were collected cross-sectionally.
The mean follow-up time was 7.9 +/- 4.1 years (range, 0.8 to 15.7 years). A pacemaker was implanted in 28 patients (21%); 54% were implanted before hospital discharge. The 10-year survival of patients with a pacemaker was higher (94%) than of patients without a pacemaker (59%; p = 0.050). The need of a pacemaker was related to a significantly higher rate of transient ischemic attacks (30% vs 6%, p = 0.004), strokes (9% vs 4%; p = 0.008), and impaired physical capacity in terms of higher New York Heart Association functional class (p = 0.03) and the quality of life scores describing energy (31 vs 17; p = 0.01) and mobility (32 vs 17; p = 0.005).
The need for pacemaker implantation after tricuspid valve operations was high. Unexpectedly, the life expectancy of the patients who needed a pacemaker postoperatively was higher compared with those who did not. This beneficial effect on mortality was offset by impaired morbidity: patients with a pacemaker experienced a significantly higher rate of thromboembolic complications and impaired quality of life.
我们研究了三尖瓣手术后永久性起搏器植入的发生率、预测因素及其对患者生存、发病率和生活质量等预后的影响。
1992年至2007年间,136例连续患者在库奥皮奥大学医院接受了三尖瓣修复或生物瓣膜置换术。前瞻性记录了全面的临床数据。横断面收集了用于诺丁汉健康状况生活质量分析的数据。
平均随访时间为7.9±4.1年(范围0.8至15.7年)。28例患者(21%)植入了起搏器;54%在出院前植入。植入起搏器患者的10年生存率(94%)高于未植入起搏器的患者(59%;p = 0.050)。起搏器的需求与短暂性脑缺血发作的发生率显著较高(30%对6%,p = 0.004)、中风(9%对4%;p = 0.008)以及纽约心脏协会功能分级较高(p = 0.03)所反映的身体能力受损以及描述精力(31对17;p = 0.01)和活动能力(32对17;p = 0.005)的生活质量评分有关。
三尖瓣手术后起搏器植入的需求较高。出乎意料的是,术后需要起搏器的患者的预期寿命高于不需要的患者。这种对死亡率的有益影响被发病率受损所抵消:植入起搏器的患者血栓栓塞并发症发生率显著较高且生活质量受损。