Goffard Nicolas, Frickey Tancred, Weiller Georg
ARC Centre of Excellence for Integrative Legume Research, Genomic Interactions Group, School of Biology, Australian National University, Canberra ACT 2601, Australia.
Nucleic Acids Res. 2009 Jul;37(Web Server issue):W335-9. doi: 10.1093/nar/gkp432. Epub 2009 May 27.
The post-genomic era presents us with the challenge of linking the vast amount of raw data obtained with transcriptomic and proteomic techniques to relevant biological pathways. We present an update of PathExpress, a web-based tool to interpret gene-expression data and explore the metabolic network without being restricted to predefined pathways. We define the Enzyme Neighbourhood (EN) as a sub-network of linked enzymes with a limited path length to identify the most relevant sub-networks affected in gene-expression experiments. PathExpress is freely available at: http://bioinfoserver.rsbs.anu.edu.au/utils/PathExpress/.
后基因组时代给我们带来了一项挑战，即要将通过转录组学和蛋白质组学技术获得的大量原始数据与相关生物途径联系起来。我们介绍了PathExpress的更新版本，这是一个基于网络的工具，用于解释基因表达数据并探索代谢网络，而不受限于预定义的途径。我们将酶邻域（EN）定义为具有有限路径长度的相连酶的子网络，以识别在基因表达实验中受影响的最相关子网络。PathExpress可在以下网址免费获取：http://bioinfoserver.rsbs.anu.edu.au/utils/PathExpress/ 。
