Materials Science and Chemical Engineering Department, Politecnico di Torino, Corso Duca degli Abruzzi 24, 10129 Torino, Italy.
J Mater Sci Mater Med. 2009 Nov;20(11):2197-205. doi: 10.1007/s10856-009-3788-z. Epub 2009 May 28.
Glass-ceramic scaffolds mimicking the structure of cancellous bone were produced via sponge replication technique by using a polyurethane foam as template and glass powder below 30 lm as inorganic phase. Specifically, a SiO₂-based glass of complex composition and its corresponding P₂O₅-based "specular" glass were used as materials for scaffolding. The polymeric sponge was thermally removed and the glass powders were sintered to obtain a replica of the template structure. The scaffolds were investigated and compared from a structural, morphological and mechanical viewpoint by assessing their crystalline phases, volumetric shrinkage, pores content and interconnection, mechanical strength. In addition, the scaffolds were soaked in acellular simulated body fluid to investigate their in vitro behaviour. The produced scaffolds have a great potential for bone reconstructive surgery because their features, such as shape, strength, bioactivity and bioresorption, can be easily tailored according to the end use.
通过使用聚氨酯泡沫作为模板和小于 30 微米的玻璃粉末作为无机相，采用海绵复制技术制备了模拟松质骨结构的微晶玻璃支架。具体而言，使用基于 SiO₂的复杂组成玻璃和相应的基于 P₂O₅的“镜面”玻璃作为支架材料。将聚合物海绵进行热去除，并将玻璃粉末进行烧结，以获得模板结构的复制品。从结构、形态和力学角度评估了支架的结晶相、体积收缩、孔隙含量和连通性、力学强度等性能，并对其进行了研究和比较。此外，还将支架浸泡在无细胞模拟体液中，以研究其体外行为。由于其特性，如形状、强度、生物活性和生物吸收性，可以根据最终用途进行轻松定制，因此所制备的支架在骨重建手术中有很大的应用潜力。
