典型的2-半胱氨酸过氧化物酶——结构、机制与功能
Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
作者信息
Hall Andrea, Karplus P A, Poole Leslie B
机构信息
Department of Biochemistry and Biophysics, Oregon State University, Corvallis, OR, USA.
出版信息
FEBS J. 2009 May;276(9):2469-77. doi: 10.1111/j.1742-4658.2009.06985.x. Epub 2009 Mar 24.
Abstract
Peroxiredoxins are abundant cellular antioxidant proteins that help to control intracellular peroxide levels. These proteins may also function, in part, through an evolved sensitivity of some peroxiredoxins towards peroxide-mediated inactivation in hydrogen peroxide signaling in eukaryotes. This review summarizes recent progress in our understanding of the catalytic and regulatory mechanisms of 'typical 2-Cys' peroxiredoxins and of the biological roles played by these important enzymes in oxidative stress and nonstress-related cellular signaling. New evidence suggests localized peroxide buildup plays a role in nonstress-related signaling.
摘要
过氧化物酶是丰富的细胞抗氧化蛋白，有助于控制细胞内过氧化物水平。这些蛋白质还可能部分通过一些过氧化物酶对真核生物中过氧化氢信号传导中过氧化物介导的失活的进化敏感性来发挥作用。本综述总结了我们对“典型2-半胱氨酸”过氧化物酶的催化和调节机制以及这些重要酶在氧化应激和非应激相关细胞信号传导中所起生物学作用的最新认识。新证据表明局部过氧化物积累在非应激相关信号传导中起作用。
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