微小棒状杆菌对小鼠单纯疱疹病毒感染的保护作用。
Protection against herpes simplex virus infection in mice by Corynebacterium parvum.
作者信息
Kirchner H, Hirt H M, Munk K
出版信息
Infect Immun. 1977 Apr;16(1):9-11. doi: 10.1128/iai.16.1.9-11.1977.
Abstract
Corynebacterium parvum administered in mice prior to herpes simplex virus (HSV) infection significantly protected them against lethal encephalitis. This was seen both with a mouse strain highly susceptible to HSV and with one relatively resistant to HSV. Mice immunosuppressed by cyclophosphamide and showing an increased mortality after HSV infection were also protected by C. parvum pretreatment. However, C. parvum given simultaneously with or after HSV infection did not exert a therapeutic effect.
摘要
在单纯疱疹病毒（HSV）感染小鼠之前给予微小棒状杆菌，可显著保护它们免受致命性脑炎的侵害。在对HSV高度易感的小鼠品系和对HSV相对有抗性的小鼠品系中均观察到这种情况。用环磷酰胺免疫抑制且在HSV感染后死亡率增加的小鼠，也受到微小棒状杆菌预处理的保护。然而，在HSV感染同时或之后给予微小棒状杆菌并没有发挥治疗作用。
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