Leggio Lorenzo, Ray Lara A, Kenna George A, Swift Robert M
Center for Alcohol and Addiction Studies, Brown University, Providence, RI 02912, USA.
Alcohol Clin Exp Res. 2009 Sep;33(9):1539-44. doi: 10.1111/j.1530-0277.2009.00982.x. Epub 2009 May 26.
Heavy drinking may increase blood glucose levels. Moreover, in alcohol-dependent subjects, glucose may play a putative role in alcohol preference.
This study investigated the relationship between blood glucose levels and both alcohol heavy drinking and craving in alcohol-dependent subjects participating in the COMBINE Study. The primary objective was to evaluate the relationship between baseline (pretreatment) glucose levels and percentage of heavy drinking day (PHDD) during treatment. The secondary objective was to evaluate the relationship between glucose levels, baseline PHDD, and craving measured by the Obsessive Compulsive Drinking Scale (OCDS).
This analysis consisted of 1,324 participants. Baseline glucose levels were significantly and positively associated with PHDD during treatment [F(1, 1225) = 5.21, p = 0.023], after controlling for baseline PHDD [F(1, 1225) = 36.25, p < 0.0001], gender [F (1, 1225) = 3.33, p = 0.07], and body mass index (BMI) [F(1, 1225) = 0.31, p = 0.58]. Higher glucose levels at baseline were associated with a higher percentage of PHDD at pretreatment [F(1, 1304) = 5.96, p = 0.015], after controlling for gender [F(1, 1304) = 0.29, p = 0.59] and BMI [F(1, 1304) = 0.90, p = 0.34]. Glucose was not significantly associated with the OCDS total score [F(1, 1304) = 0.12, p = 0.73], the OCDS Obsessive subscale [F(1, 1304) = 0.35, p = 0.56], or the OCDS Compulsive subscale [F(1, 1304) = 1.19, p = 0.28] scores, after controlling for gender and BMI.
A link between pretreatment glucose levels and heavy drinking during treatment was found, suggesting a role of glucose in predicting heavy alcohol consumption. Although caution is needed in the interpretation of these results, elevated glucose and heavy drinking may be affected by a common mechanism and manipulations affecting glucose regulation may influence alcohol consumption.
大量饮酒可能会升高血糖水平。此外，在酒精依赖者中，葡萄糖可能在酒精偏好方面发挥假定作用。
本研究调查了参与联合研究的酒精依赖者的血糖水平与大量饮酒及渴望饮酒之间的关系。主要目标是评估基线（治疗前）血糖水平与治疗期间重度饮酒日百分比（PHDD）之间的关系。次要目标是评估血糖水平、基线PHDD以及通过强迫性饮酒量表（OCDS）测量的渴望饮酒之间的关系。
该分析纳入了1324名参与者。在控制了基线PHDD [F(1, 1225) = 36.25, p < 0.0001]、性别 [F (1, 1225) = 3.33, p = 0.07] 和体重指数（BMI）[F(1, 1225) = 0.31, p = 0.58] 后，基线血糖水平与治疗期间的PHDD显著正相关 [F(1, 1225) = 5.21, p = 0.023]。在控制了性别 [F(1, 1304) = 0.29, p = 0.59] 和BMI [F(1, 1304) = 0.90, p = 0.34] 后，基线时较高的血糖水平与治疗前较高的PHDD百分比相关 [F(1, 1304) = 5.96, p = 0.015]。在控制了性别和BMI后，血糖与OCDS总分 [F(1, 1304) = 0.12, p = 0.73]、OCDS强迫观念分量表 [F(1, 1304) = 0.35, p = 0.56] 或OCDS强迫行为分量表 [F(1, 1304) = 1.19, p = 0.28] 得分均无显著相关性。
发现治疗前血糖水平与治疗期间大量饮酒之间存在关联，提示葡萄糖在预测大量饮酒方面发挥作用。尽管在解释这些结果时需要谨慎，但血糖升高和大量饮酒可能受共同机制影响，影响血糖调节的操作可能会影响酒精摄入。
