Günther Jeannette, Ramírez-Palacio Luis Román, Pérez-Ishiwara David Guillermo, Salas-Benito Juan Santiago
Programa Institucional de Biomedicina Molecular, Escuela Nacional de Medicina y Homeopatía del Instituto Politécnico Nacional, México, Mexico.
J Clin Virol. 2009 Jul;45(3):218-22. doi: 10.1016/j.jcv.2009.05.007. Epub 2009 May 31.
Dengue virus infection is an emergent viral disease and the most important transmitted by a vector worldwide. In Mexico it has been an important public health problem since 1995 and Oaxaca is one of the most affected states in the country.
To determine the geographic distribution of confirmed dengue cases in the state of Oaxaca, Mexico, the serotypes circulating, and the main gender and age groups affected.
Information about confirmed dengue cases obtained by LESPO during the period 2004-2006 was classified, sorted, and analysed. A RT-PCR technique was used to determine the serotype of the virus in serum samples.
A substantial increment in the number of dengue cases was noticed during the period of this study. The most affected sanitary jurisdiction was located on the coast where the climatic conditions were ideal for vector development and where there is significant migratory activity. The most affected group was the 11-15-year-old group. Dengue haemorrhagic fever was more frequent in men than in women over 16 years old, with a significant difference evaluated by chi(2)-test (p<0.001). Four serotypes of the virus were detected in the state and two co-infections with DEN2-3 and DEN3-4 were identified.
The increment in the number of dengue cases in the state of Oaxaca could be explained by several factors such as the presence of the four serotypes of the virus, the migratory phenomenon, the climatic conditions and the socioeconomic level of the population.
登革病毒感染是一种新发病毒性疾病，也是全球最重要的媒介传播疾病。自1995年以来，它在墨西哥一直是一个重要的公共卫生问题，瓦哈卡州是该国受影响最严重的州之一。
确定墨西哥瓦哈卡州确诊登革热病例的地理分布、流行的血清型以及受影响的主要性别和年龄组。
对2004 - 2006年期间地方流行病学监测系统（LESPO）获得的确诊登革热病例信息进行分类、整理和分析。采用逆转录聚合酶链反应（RT-PCR）技术测定血清样本中病毒的血清型。
在本研究期间，登革热病例数量大幅增加。受影响最严重的卫生辖区位于沿海地区，那里的气候条件非常适合病媒滋生，且存在大量迁徙活动。受影响最严重的群体是11 - 15岁年龄组。16岁以上男性登革出血热的发病率高于女性，经卡方检验评估存在显著差异（p<0.001）。该州检测到四种病毒血清型，并鉴定出两例DEN2 - 3和DEN3 - 4的共同感染病例。
瓦哈卡州登革热病例数量的增加可能由多种因素解释，如病毒四种血清型的存在、迁徙现象、气候条件以及人群的社会经济水平。
