在墨西哥，血清型对妊娠状态下登革热严重程度的调节作用。

Moderation effects of serotype on dengue severity across pregnancy status in Mexico.

机构信息

Department of Biostatistics & Epidemiology, University of North Texas Health Science Center, Fort Worth, TX, USA.

Center for Health and Wellbeing, School of Public and International Affairs, Princeton University, Princeton, NJ, USA.

出版信息

BMC Infect Dis. 2023 Mar 10;23(1):147. doi: 10.1186/s12879-023-08051-z.

DOI:10.1186/s12879-023-08051-z

PMID:36899304

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9999597/

Abstract

BACKGROUND

Pregnancy increases a woman's risk of severe dengue. To the best of our knowledge, the moderation effect of the dengue serotype among pregnant women has not been studied in Mexico. This study explores how pregnancy interacted with the dengue serotype from 2012 to 2020 in Mexico.

METHOD

Information from 2469 notifying health units in Mexican municipalities was used for this cross-sectional analysis. Multiple logistic regression with interaction effects was chosen as the final model and sensitivity analysis was done to assess potential exposure misclassification of pregnancy status.

RESULTS

Pregnant women were found to have higher odds of severe dengue [1.50 (95% CI 1.41, 1.59)]. The odds of dengue severity varied for pregnant women with DENV-1 [1.45, (95% CI 1.21, 1.74)], DENV-2 [1.33, (95% CI 1.18, 1.53)] and DENV-4 [3.78, (95% CI 1.14, 12.59)]. While the odds of severe dengue were generally higher for pregnant women compared with non-pregnant women with DENV-1 and DENV-2, the odds of disease severity were much higher for those infected with the DENV-4 serotype.

CONCLUSION

The effect of pregnancy on severe dengue is moderated by the dengue serotype. Future studies on genetic diversification may potentially elucidate this serotype-specific effect among pregnant women in Mexico.

摘要

背景

妊娠会增加女性患重症登革热的风险。据我们所知，尚未在墨西哥研究妊娠与登革热血清型之间的调节作用。本研究旨在探讨 2012 年至 2020 年期间，妊娠与墨西哥登革热血清型之间的相互作用。

方法

本横断面分析使用了来自墨西哥市 2469 个通报卫生单位的信息。选择具有交互作用的多变量逻辑回归作为最终模型，并进行敏感性分析以评估妊娠状态的潜在暴露错误分类。

结果

与非妊娠女性相比，妊娠女性发生重症登革热的几率更高[1.50（95%置信区间 1.41, 1.59)]。妊娠女性中 DENV-1[1.45，（95%置信区间 1.21, 1.74)]、DENV-2[1.33，（95%置信区间 1.18, 1.53)]和 DENV-4[3.78，（95%置信区间 1.14, 12.59)]的严重登革热几率存在差异。虽然与非妊娠女性相比，妊娠女性感染 DENV-1 和 DENV-2 时发生重症登革热的几率通常更高，但感染 DENV-4 血清型时疾病严重程度的几率要高得多。