Stenager E, Knudsen L, Jensen K
Clinical Neuro-Psychiatric Research Unit, Odense University, Denmark.
Acta Neurol Scand. 1991 Sep;84(3):197-200. doi: 10.1111/j.1600-0404.1991.tb04937.x.
A representative sample of 117 patients with definite multiple sclerosis (MS) was interviewed on pain syndromes. Chronic syndromes lasting more than one month included dysaestesthesia, low back pain, spasms, tonic seizures, tightening and painful sensations in the extremities. Acute syndromes included neuralgia, L'Hermitte's sign and pain associated with optic neuritis. Thirty-five per cent were pain-free. Of the remaining patients had 45% pain at the time of the examination, 32% indicated pain among the most severe symptoms of MS and 23% had pain at the onset of MS. The number of patients with pain at the time of the examination increased with age and duration of disease. Patients with pain were significantly more often spastic and significantly more often sought alternative treatment forms. No difference was found for mean age, sex, physical impairment, duration of disease from onset of MS, depressive score and score of delayed verbal memory.
对117例确诊为多发性硬化症（MS）的患者进行了关于疼痛综合征的访谈。持续超过一个月的慢性综合征包括感觉异常、腰痛、痉挛、强直性发作、四肢紧绷和疼痛感觉。急性综合征包括神经痛、莱尔米特征和与视神经炎相关的疼痛。35%的患者无疼痛。其余患者中，45%在检查时有疼痛，32%表示疼痛是MS最严重的症状之一，23%在MS发病时有疼痛。检查时疼痛患者的数量随年龄和病程增加。疼痛患者痉挛的情况明显更常见，并且明显更常寻求替代治疗方式。在平均年龄、性别、身体损伤、从MS发病起的病程、抑郁评分和延迟言语记忆评分方面未发现差异。
