Department of Dermatology, Baskent University School of Medicine, Ankara, Turkey.
Clin Exp Dermatol. 2009 Oct;34(7):789-92. doi: 10.1111/j.1365-2230.2008.03165.x. Epub 2009 Apr 8.
Cutaneous dysaesthesia syndromes are characterized by chronic cutaneous symptoms without objective findings, and their aetiologies are obscure. Trichodynia describes pain and a stinging sensation of the scalp related to diffuse alopecia.
To determine the prevalence rate of trichodynia in patients with diffuse alopecia; to assess the serum zinc, folate and vitamin B(12) levels; and to investigate the significance of psychological disorders in these patients.
The study comprised 91 patients with a diagnosis of diffuse hair loss and 74 healthy controls. Patients were questioned about the presence of trichodynia, and their serum zinc, folate and vitamin B(12) levels were assessed. They were also evaluated using the Beck Depression Inventory (BDI), the Beck Anxiety Inventory, and the Somatoform Dissociation Questionnaire (SDQ).
The rates of androgenetic alopecia and telogen effluvium were 26.4% and 73.6%, respectively, Trichodynia was found in 30 patients (33%), and was more common in the telogen effluvium group than in the androgenetic alopecia group (P = 0.5). There was no significant difference between the patients with alopecia and controls for zinc, folate and vitamin B(12) levels, or for psychological test scores. However, the BDI and SDQ scores were significantly higher (P = 0.03 and P = 0.01, respectively) in patients with than those in without trichodynia.
Trichodynia is a commonly encountered symptom in patients with diffuse alopecia, and depression and somatoform dissociation disorders may play an important role in its aetiology. Our data provide no evidence that serum levels of zinc, folate or vitamin B(12) are involved in the pathogenesis of trichodynia.
皮肤感觉异常综合征的特征是慢性皮肤症状而无客观发现，其病因不明。头皮痛描述与弥漫性脱发相关的头皮疼痛和刺痛感。
确定弥漫性脱发患者中头皮痛的患病率；评估血清锌、叶酸和维生素 B₁₂ 水平；并研究这些患者心理障碍的意义。
本研究包括 91 例弥漫性脱发患者和 74 例健康对照者。询问患者是否存在头皮痛，并评估其血清锌、叶酸和维生素 B₁₂ 水平。还使用贝克抑郁量表（BDI）、贝克焦虑量表和躯体化分离问卷（SDQ）进行评估。
雄激素性脱发和休止期脱发的发生率分别为 26.4%和 73.6%。30 例（33%）患者存在头皮痛，且休止期脱发组比雄激素性脱发组更常见（P=0.5）。脱发患者与对照组之间在锌、叶酸和维生素 B₁₂ 水平或心理测试评分方面均无显著差异。然而，BDI 和 SDQ 评分在有头皮痛的患者中显著高于无头皮痛的患者（P=0.03 和 P=0.01）。
头皮痛是弥漫性脱发患者常见的症状，抑郁和躯体化分离障碍可能在其发病机制中起重要作用。我们的数据没有证据表明血清锌、叶酸或维生素 B₁₂ 水平参与了头皮痛的发病机制。
