Stakleff K D Sloan, Von Gruenigen V E
Kenneth Calhoun Research Laboratory, Akron General Medical Center, Akron, Ohio USA.
Int J Gynecol Cancer. 2003 Jul-Aug;13(4):405-12. doi: 10.1046/j.1525-1438.2003.13317.x.
Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer.
具有生物学和临床相关性的动物模型对于开展研究以调查疾病的病理生理进展以及制定诊断或治疗策略至关重要。几种诱导方法各异的啮齿动物模型可用于对卵巢癌进行合适的体内评估。所讨论的啮齿动物模型类型包括化学诱导（非激素和激素）、基因（敲除和转基因）、异种移植和同基因模型。本文提供了现有啮齿动物模型的总结，并讨论了每种模型的优缺点。将这些啮齿动物模型优化并应用于未来研究可能会有益于卵巢癌的检测和治疗。
