Shkurupiy V A, Dubinin E V, Dubinina N N
Center of Clinical and Experimental Medicine, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2008 Dec;146(6):845-8. doi: 10.1007/s10517-009-0403-8.
Myocytes with large homogeneous vacuoles and numerous protrusions of the cytoplasm into extracellular space (manifestations of clasmatosis) were detected in rat myometrium during normal gestation and early postpartum period. The percentage of vacuolated smooth-muscle cells and numerical density of inflammatory cells in the myometrium were evaluated. The data indicate the absence of typical inflammatory reaction in the myometrium during elimination of smooth-muscle cells in the course of postpartum involution. Clasmatosis and apoptosis are hypothesized to be the main mechanisms providing reduction of the uterine weight after delivery.
在正常妊娠和产后早期的大鼠子宫肌层中，检测到含有大的均匀空泡且有大量细胞质突入细胞外空间（胞质分裂的表现）的肌细胞。评估了子宫肌层中空泡化平滑肌细胞的百分比和炎症细胞的数量密度。数据表明，在产后 involution 过程中平滑肌细胞消除期间，子宫肌层不存在典型的炎症反应。推测胞质分裂和细胞凋亡是分娩后子宫重量减轻的主要机制。
