Skurupiy V A, Obedinskaya K S, Nadeev A P
Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2010 Oct;149(5):554-8. doi: 10.1007/s10517-010-0991-3.
Myocyte hypertrophy and proliferation in the myometrium were observed in mice during the first pregnancy and involution of the myometrium was completed by day 10 postpartum. Parameters of all structures returned to values observed in intact uterus. During the third pregnancy, the processes of myometrium hypertrophy were similar to those during the first pregnancy, but the intensity of proliferation was higher against the background of poorer vascularization, which led to destruction of some myocytes. Postpartum involution of the myometrium in these mice was not completed by day 10 after delivery. We observed hypertrophy and proliferation of some myocytes followed by their destruction, decrease in vessel number, and many-fold decrease in collagen content in the myometrial interstitium. The number of fetuses in the litter decreased after multiple pregnancies.
在首次怀孕的小鼠子宫肌层中观察到了肌细胞肥大和增殖，产后第10天子宫肌层的 involution 完成。所有结构的参数恢复到完整子宫中观察到的值。在第三次怀孕期间，子宫肌层肥大过程与首次怀孕时相似，但在血管化较差的背景下增殖强度更高，这导致一些肌细胞被破坏。这些小鼠产后第10天子宫肌层的 involution 未完成。我们观察到一些肌细胞肥大和增殖，随后是它们的破坏、血管数量减少以及子宫肌层间质中胶原蛋白含量大幅下降。多次怀孕后窝仔数减少。
