Shkurupiy V A, Obedinskaya K S, Nadeev A P
Institute of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia.
Bull Exp Biol Med. 2011 Jan;150(3):378-82. doi: 10.1007/s10517-011-1147-9.
Elimination of "excessive" myocytes and their structures during involution of the myometrium after the first and third pregnancies was realized by clasmocytosis (eliminating the greatest volume of myocyte cytoplasm fragments), apoptosis, and necrosis (equal percentage by volume). In contrast to the first pregnancy, involution after the third one was not over by day 10 because of inhibited elimination of functionally lost myocytes by necrosis and apoptosis mechanisms. Presumably, this was caused by slower hydrolysis of apoptotic bodies by macrophages. The concentration of macrophages in the myometrium on day 10 of the involution period in females after the third delivery was 4-fold higher than in intact mice and in females after the first delivery during the same period.
在第一次和第三次妊娠后子宫肌层复旧过程中，通过胞质溶解（消除最大体积的肌细胞胞质片段）、凋亡和坏死（体积百分比相等）实现了“多余”肌细胞及其结构的清除。与第一次妊娠不同，第三次妊娠后的复旧到第10天时并未完成，原因是坏死和凋亡机制对功能丧失的肌细胞的清除受到抑制。据推测，这是由于巨噬细胞对凋亡小体的水解较慢所致。在第三次分娩后雌性动物复旧期第10天时，子宫肌层中巨噬细胞的浓度比同期未孕小鼠和第一次分娩后雌性动物高4倍。
