摇瓶和生物反应器中内生菌产生喜树碱的比较研究与鉴定
Comparative studies and identification of camptothecin produced by an endophyte at shake flask and bioreactor.
作者信息
Rehman Suriya, Shawl A S, Kour Amardeep, Sultan Phalisteen, Ahmad Khurheed, Khajuria Ravi, Qazi G N
机构信息
Indian Institute of Integrative Medicine (CSIR), Sanatnagar, Srinagar, India.
出版信息
Nat Prod Res. 2009;23(11):1050-7. doi: 10.1080/14786410902750944.
PMID:19521920
Abstract
The fungus showing homology with Nodulisporium by 28S ribosomal gene sequencing, which has been discovered as an endophyte on medicinal plant Nothapodytes foetida, was found to produce 45 and 5.5 microg of camptothecin (CPT) per gram of mycelia at bioreactor and at shake flask, respectively, which was further quantified and characterised by various spectroscopic analyses.
摘要
通过28S核糖体基因测序显示与节菱孢属具有同源性的真菌，已在药用植物臭豆中作为内生菌被发现，该真菌在生物反应器和摇瓶中每克菌丝体分别产生45微克和5.5微克喜树碱（CPT），并通过各种光谱分析进一步进行了定量和表征。
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