干燥综合征患者的健康相关生活质量、就业与残疾情况

Health-related quality of life, employment and disability in patients with Sjogren's syndrome.

作者信息

Meijer Jiska M, Meiners Petra M, Huddleston Slater James J R, Spijkervet Fred K L, Kallenberg Cees G M, Vissink Arjan, Bootsma Hendrika

机构信息

Department of Oral and Maxillofacial Surgery, University Medical Center Groningen, Groningen, The Netherlands.

出版信息

Rheumatology (Oxford). 2009 Sep;48(9):1077-82. doi: 10.1093/rheumatology/kep141. Epub 2009 Jun 24.

DOI:10.1093/rheumatology/kep141

PMID:19553376

Abstract

OBJECTIVE

To compare health-related quality of life (HR-QOL), employment and disability of primary and secondary SS (pSS and sSS, respectively) patients with the general Dutch population.

METHODS

HR-QOL, employment and disability were assessed in SS patients regularly attending the University Medical Center Groningen (n = 235). HR-QOL, employment and disability were evaluated with the Short Form-36 questionnaire (SF-36) and an employment and disability questionnaire. Results were compared with Dutch population data (matched for sex and age). Demographical and clinical data associated with HR-QOL, employment and disability were assessed.

RESULTS

Response rate was 83%. SS patients scored lower on HR-QOL than the general Dutch population. sSS patients scored lower on physical functioning, bodily pain and general health than pSS patients. Predictors for reduced HR-QOL were fatigue, tendomyalgia, articular involvement, use of artificial saliva, use of anti-depressants, comorbidity, male sex and eligibility for disability compensation (DC). Employment was lower and DC rates were higher in SS patients compared with the Dutch population.

CONCLUSION

SS has a large impact on HR-QOL, employment and disability.

摘要

目的

比较原发性和继发性干燥综合征（分别为pSS和sSS）患者与荷兰普通人群的健康相关生活质量（HR-QOL）、就业情况和残疾状况。

方法

对定期前往格罗宁根大学医学中心就诊的干燥综合征患者（n = 235）进行HR-QOL、就业情况和残疾状况评估。采用简短健康调查问卷（SF-36）和一份就业与残疾调查问卷对HR-QOL、就业情况和残疾状况进行评估。将结果与荷兰人群数据（按性别和年龄匹配）进行比较。评估与HR-QOL、就业情况和残疾状况相关的人口统计学和临床数据。

结果

应答率为83%。干燥综合征患者的HR-QOL得分低于荷兰普通人群。与原发性干燥综合征患者相比，继发性干燥综合征患者在身体功能、身体疼痛和总体健康方面得分更低。HR-QOL降低的预测因素包括疲劳、肌腱肌痛、关节受累、使用人工唾液、使用抗抑郁药、合并症、男性性别以及获得残疾补偿（DC）资格。与荷兰人群相比，干燥综合征患者的就业率较低，DC率较高。