National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Bioinformatics. 2009 Sep 15;25(18):2447-9. doi: 10.1093/bioinformatics/btp398. Epub 2009 Jun 27.
Founded upon diffusion with damping, ITM Probe is an application for modeling information flow in protein interaction networks without prior restriction to the sub-network of interest. Given a context consisting of desired origins and destinations of information, ITM Probe returns the set of most relevant proteins with weights and a graphical representation of the corresponding sub-network. With a click, the user may send the resulting protein list for enrichment analysis to facilitate hypothesis formation or confirmation.
ITM Probe web service and documentation can be found at www.ncbi.nlm.nih.gov/CBBresearch/qmbp/mn/itm_probe.
基于扩散和阻尼的 ITM Probe 是一种用于在蛋白质相互作用网络中建模信息流的应用程序,无需事先限制感兴趣的子网。给定一个包含所需信息源和目标的上下文,ITM Probe 返回具有权重和相应子网图形表示的最相关蛋白质集。用户只需点击一下,就可以将生成的蛋白质列表发送到富集分析,以方便假设的形成或验证。
ITM Probe 网络服务和文档可在 www.ncbi.nlm.nih.gov/CBBresearch/qmbp/mn/itm_probe 找到。