Scansen Brian A, Bonagura John D, Schober Karsten E, Muir William W
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA.
Am J Vet Res. 2009 Jul;70(7):862-8. doi: 10.2460/ajvr.70.7.862.
To evaluate the accuracy of a commercial ultrasonographic cardiac output (CO) monitoring system (UCOMS) in anesthetized Beagles as assessed by comparison with thermodilution CO (TDCO).
8 healthy anesthetized Beagles.
Simultaneous UCOMS and TDCO measurements of CO were obtained during 4 hemodynamic states: baseline anesthesia (0.5% to 1.5% isoflurane), a higher depth of anesthesia (2% to 3.5% isoflurane) to yield a >or= 15% reduction in systolic arterial blood pressure, IV infusion of colloidal solution to a mean right atrial pressure of >or= 15 mm Hg, and IV infusion of dobutamine at 5 microg/kg/min. Measurements were obtained at 2 probe positions: the subxiphoid region and the right thoracic inlet. Correlation and agreement of results between methods were determined via linear regression analysis and Bland-Altman plots.
A significant positive correlation was detected between UCOMS andTDCO measurements obtained at the subxiphoid (R = 0.86) and thoracic inlet (R = 0.83) positions. Bland-Altman plots revealed minimal bias between methods (bias +/- SD, -0.03 +/- 0.73 L/min and -0.20 +/- 0.80 L/min for subxiphoid and thoracic inlet measurements, respectively). However, the percentage error associated with UCOMS measurements made at the 2 positions was > 45%.
When compared with the results of TDCO, CO measured with the UCOMS exceeded commonly accepted limits of error in healthy dogs. The UCOMS was, however, able to track changes in CO across hemodynamic states. Additional research is needed to assess the usefulness of the UCOMS for monitoring CO in critically ill dogs.
通过与热稀释法心输出量（TDCO）比较，评估一种商用超声心动输出量（CO）监测系统（UCOMS）在麻醉比格犬中的准确性。
8只健康麻醉比格犬。
在4种血流动力学状态下同时进行UCOMS和TDCO测量：基础麻醉（0.5%至1.5%异氟醚）、更深麻醉深度（2%至3.5%异氟醚）以使收缩期动脉血压降低≥15%、静脉输注胶体溶液使平均右心房压≥15 mmHg以及静脉输注多巴酚丁胺5 μg/kg/min。在2个探头位置进行测量：剑突下区域和右胸入口。通过线性回归分析和Bland-Altman图确定方法间结果的相关性和一致性。
在剑突下（R = 0.86）和胸入口（R = 0.83）位置获得的UCOMS和TDCO测量值之间检测到显著正相关。Bland-Altman图显示方法间偏差极小（偏差±标准差，剑突下和胸入口测量分别为-0.03±0.73 L/min和-0.20±0.80 L/min）。然而，在这2个位置进行的UCOMS测量相关的百分比误差>45%。
与TDCO结果相比，用UCOMS测量的CO超出了健康犬普遍接受的误差限度。然而，UCOMS能够追踪血流动力学状态下心输出量的变化。需要进一步研究评估UCOMS在危重病犬中监测心输出量方面的实用性。
