Minagawa-Kawai Yasuyo, Naoi Nozomi, Kikuchi Naoko, Yamamoto Jun-Ichi, Nakamura Katsuki, Kojima Shozo
Graduate School of Human Relations, Keio University, Mita, Minato-ku, Tokyo, Japan.
Neuroreport. 2009 Aug 26;20(13):1219-24. doi: 10.1097/WNR.0b013e32832fa65f.
This study examined the cerebral functional lateralization, from a phonological perspective, in children with autism spectrum disorder (ASD) and typically developing children (TDC). With near infrared spectroscopy, we measured auditory evoked-responses in the temporal areas to phonemic and prosodic contrasts in word contexts. The results of TDC showed stronger left-dominant and right-dominant responses to phonemic and prosodic differences, respectively. Furthermore, although ASD children displayed similar tendencies, the functional asymmetry for phonemic changes was relatively weak, suggesting less-specialized left-brain functions. The typical asymmetry for the prosodic condition was further discussed in terms of acoustic-physical perceptual ability of ASD children. The study revealed differential neural recruitment in decoding phonetic cues between ASD children and TDC and verified the applicability of near infrared spectroscopy as a suitable neuroimaging method for children with developmental disorders.
本研究从语音学角度考察了自闭症谱系障碍（ASD）儿童和发育正常儿童（TDC）的大脑功能偏侧化情况。我们使用近红外光谱技术，测量了颞叶区域对单词语境中语音和韵律对比的听觉诱发反应。TDC的结果显示，对语音差异和韵律差异分别表现出更强的左脑优势和右脑优势反应。此外，虽然ASD儿童也表现出类似趋势，但语音变化的功能不对称相对较弱，表明左脑功能的专业化程度较低。针对韵律条件下的典型不对称，根据ASD儿童的声学-物理感知能力进行了进一步讨论。该研究揭示了ASD儿童和TDC在解码语音线索时神经募集的差异，并验证了近红外光谱技术作为一种适用于发育障碍儿童的神经成像方法的适用性。
