白细胞介素-17和白细胞介素-22与抵御杜氏利什曼原虫引起的人类黑热病有关。
IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani.
作者信息
Pitta Maira G R, Romano Audrey, Cabantous Sandrine, Henri Sandrine, Hammad Awad, Kouriba Bouréma, Argiro Laurent, el Kheir Musa, Bucheton Bruno, Mary Charles, El-Safi Sayda Hassan, Dessein Alain
机构信息
INSERM, Unité 906, Marseille, France.
出版信息
J Clin Invest. 2009 Aug;119(8):2379-87. doi: 10.1172/JCI38813. Epub 2009 Jul 13.
Abstract
IL-17 and IL-22 have been shown to increase protection against certain bacteria and fungal pathogens in experimental models. However, no human studies have demonstrated a crucial role of IL-17 and IL-22 in protection against infections. We show here that Leishmania donovani, which can cause the lethal visceral disease Kala Azar (KA), stimulates the differentiation of Th17 cells, which produce IL-17, IL-22, and IFN-gamma. Analysis of Th1, Th2, and Th17 cytokine responses by cultured PBMCs from individuals in a cohort of subjects who developed KA or were protected against KA during a severe outbreak showed that IL-17 and IL-22 were strongly and independently associated with protection against KA. Our results suggest that, along with Th1 cytokines, IL-17 and IL-22 play complementary roles in human protection against KA, and that a defect in Th17 induction may increase the risk of KA.
摘要
在实验模型中，白细胞介素-17（IL-17）和白细胞介素-22（IL-22）已被证明能增强对某些细菌和真菌病原体的抵抗力。然而，尚无人体研究表明IL-17和IL-22在抗感染中起关键作用。我们在此表明，可导致致命性内脏疾病黑热病（KA）的杜氏利什曼原虫能刺激产生IL-17、IL-22和干扰素-γ的辅助性T细胞17（Th17细胞）分化。对在一次严重疫情中患KA或对KA有抵抗力的一组受试者的外周血单核细胞（PBMC）进行培养，分析其Th1、Th2和Th17细胞因子反应，结果显示IL-17和IL-22与对KA的抵抗力密切且独立相关。我们的研究结果表明，与Th1细胞因子一起，IL-17和IL-22在人体对KA的抵抗力中起互补作用，并且Th17诱导缺陷可能会增加患KA的风险。
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本文引用的文献
1
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Annu Rev Immunol. 2009;27:485-517. doi: 10.1146/annurev.immunol.021908.132710.
2
IL-21 and IL-21R are not required for development of Th17 cells and autoimmunity in vivo.体内Th17细胞的发育和自身免疫并不需要IL-21和IL-21R。
Eur J Immunol. 2008 Jul;38(7):1833-8. doi: 10.1002/eji.200838511.
3
Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis.前沿：白细胞介素-21对于辅助性T细胞17分化或实验性自身免疫性脑脊髓炎并非必不可少。
J Immunol. 2008 Jun 1;180(11):7097-101. doi: 10.4049/jimmunol.180.11.7097.
4
Immunological and genetic evidence for a crucial role of IL-10 in cutaneous lesions in humans infected with Leishmania braziliensis.白细胞介素-10在巴西利什曼原虫感染人类皮肤病变中起关键作用的免疫学和遗传学证据。
J Immunol. 2008 May 1;180(9):6139-48. doi: 10.4049/jimmunol.180.9.6139.
5
TH17 cells in development: an updated view of their molecular identity and genetic programming.发育中的辅助性T细胞17：其分子特性与基因编程的最新观点
Nat Rev Immunol. 2008 May;8(5):337-48. doi: 10.1038/nri2295.
6
The biological functions of T helper 17 cell effector cytokines in inflammation.辅助性T细胞17效应细胞因子在炎症中的生物学功能
Immunity. 2008 Apr;28(4):454-67. doi: 10.1016/j.immuni.2008.03.004.
7
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Nat Med. 2008 Mar;14(3):282-9. doi: 10.1038/nm1720. Epub 2008 Feb 10.
8
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Scand J Immunol. 2008 Mar;67(3):238-44. doi: 10.1111/j.1365-3083.2007.02063.x.
9
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