Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan.
Am J Gastroenterol. 2009 Dec;104(12):2942-8. doi: 10.1038/ajg.2009.426. Epub 2009 Jul 21.
The narrow-band imaging (NBI) system is a novel technology that enhances the visualization of microvasculature and mucosal patterns. The aim of this study was to assess the reliability of the NBI system for esophageal cancer screening in patients with head and neck cancers.
A total of 142 patients with head and neck squamous cell carcinoma (SCC) were examined by NBI endoscopy, followed by Lugol chromoendoscopy between April 2006 and June 2008 at the Okayama University Hospital, Okayama, Japan. Detection of SCC and high-grade intraepithelial neoplasia (HGIN) was conducted.
The median age of the patients was 64 years (range: 29-86 years), and approximately three-fourths of all the patients were male. In total, 21 superficial lesions in 16 patients were detected by NBI endoscopy. Of these, 4 lesions were diagnosed histologically as SCC and 11 lesions as HGIN. An additional 22 Lugol-voiding lesions >or=5 mm were detected in 19 patients by Lugol chromoendoscopy. Although 1 of these lesions was diagnosed as HGIN, 21 lesions were diagnosed as low-grade intraepithelial neoplasia or lesions without atypical findings. The sensitivity of NBI endoscopy for detecting esophageal SCC and HGIN was 90.9% (95% confidence interval (CI), 58.7-99.8), specificity was 95.4% (95% CI, 90.3-98.3), and accuracy was 95.1% (95% CI, 90.1-98.0).
NBI seems to be useful and reliable for screening for esophageal SCC in patients with head and neck cancers.
窄带成像（NBI）系统是一种增强微血管和黏膜模式可视化的新技术。本研究旨在评估 NBI 系统对头颈癌患者食管癌筛查的可靠性。
2006 年 4 月至 2008 年 6 月期间，在日本冈山大学医院，对 142 例头颈部鳞状细胞癌（SCC）患者进行了 NBI 内镜检查，随后进行了卢戈氏染色内镜检查。对 SCC 和高级上皮内瘤变（HGIN）进行了检测。
患者的中位年龄为 64 岁（范围：29-86 岁），约四分之三的患者为男性。NBI 内镜共检出 16 例患者的 21 处浅表病变。其中，4 处病变组织学诊断为 SCC，11 处病变诊断为 HGIN。卢戈氏染色内镜还检出 19 例患者的 22 处 >或=5mm 的卢戈氏染色缺失病变。虽然其中 1 处病变诊断为 HGIN，但 21 处病变诊断为低级别上皮内瘤变或无异型增生的病变。NBI 内镜检测食管 SCC 和 HGIN 的敏感性为 90.9%（95%置信区间（CI），58.7-99.8），特异性为 95.4%（95% CI，90.3-98.3），准确性为 95.1%（95% CI，90.1-98.0）。
NBI 似乎对头颈癌患者的食管癌筛查有用且可靠。
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