Valarcher Jean Francois, Knowles Nick J, Zakharov Valery, Scherbakov Alexey, Zhang Zhidong, Shang You Jun, Liu Zai Xin, Liu Xiang Tao, Sanyal Aniket, Hemadri Divakar, Tosh Chakradhar, Rasool Thaha J, Pattnaik Bramhadev, Schumann Kate R, Beckham Tammy R, Linchongsubongkoch Wilai, Ferris Nigel P, Roeder Peter L, Paton David J
Institute for Animal Health, Pirbright, UK.
Emerg Infect Dis. 2009 Jul;15(7):1046-51. doi: 10.3201/eid1507.081621.
We investigated the molecular epidemiology of foot-and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea. Phylogenetic analysis of complete virus capsid protein 1 (VP1) gene sequences demonstrated that the FMDV isolates responsible for these outbreaks belonged to 6 groups within the Asia 1 serotype. Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago. Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.
我们调查了亚洲1型口蹄疫病毒（FMDV）的分子流行病学情况，该病毒在2003年至2007年期间于亚洲引发了疾病疫情。自2004年以来，受该血清型疫情影响的地区已从南亚的疾病流行国家（阿富汗、印度、伊朗、尼泊尔、巴基斯坦）向北扩展，涵盖了吉尔吉斯斯坦、塔吉克斯坦、乌兹别克斯坦、中华人民共和国的几个地区、蒙古、俄罗斯东部和朝鲜。对完整病毒衣壳蛋白1（VP1）基因序列的系统发育分析表明，导致这些疫情的FMDV分离株属于亚洲1型血清型内的6个组。一些当代菌株在基因上与早在25年前从该地区采集的分离株密切相关。我们的分析还表明，一些病毒在短时间内在亚洲国家之间远距离传播。
