在马来西亚海洋甲藻原甲藻培养株中发现了冈田酸的产生。
Evidence of okadaic acid production in a cultured strain of the marine dinoflagellate Prorocentrum rhathymum from Malaysia.
机构信息
IRTA, Ctra. Poble Nou, km. 5.5, 43540 Sant Carles de la Ràpita, Spain.
出版信息
Toxicon. 2010 Feb-Mar;55(2-3):633-7. doi: 10.1016/j.toxicon.2009.07.016. Epub 2009 Jul 23.
Abstract
Protein phosphatase inhibition assay (PPIA), Neuroblastoma cell-based assay (Neuro-2a CBA) and LC-MS/MS analysis revealed for the first time the production of okadaic acid (OA) by a Prorocentrum rhathymum strain. Low amounts of OA were detected by LC-MS/MS analysis. Inhibition of PP2A activity and a weak toxicity to the Neuro-2a CBA were also observed.
摘要
蛋白磷酸酶抑制 assay（PPIA）、基于神经母细胞瘤细胞的 assay（Neuro-2a CBA）和 LC-MS/MS 分析首次揭示了原甲藻属（Prorocentrum rhathymum）菌株产生 okadaic acid（OA）的情况。通过 LC-MS/MS 分析检测到少量 OA。还观察到对 PP2A 活性的抑制和对 Neuro-2a CBA 的轻微毒性。
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