Gastroenterology Division, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada.
Clin Gastroenterol Hepatol. 2010 May;8(5):401-9. doi: 10.1016/j.cgh.2009.07.020. Epub 2009 Jul 23.
BACKGROUND & AIMS: Dyspepsia and irritable bowel syndrome (IBS) are common conditions that can coexist in patients. We performed a systematic review and meta-analysis to estimate prevalence of IBS in dyspepsia.
Relevant articles published through August 2008 were identified from MEDLINE and EMBASE literature searches (23,457 citations). Eligible studies included adults recruited from the community, the workplace, blood donation or screening clinics, and family physician offices or internal medicine clinics. Selected studies reported prevalence of dyspepsia and IBS within the same population. The prevalence of IBS in subjects with and without dyspepsia was pooled for all studies and compared. Odds ratios (OR) and confidence intervals (CI) were calculated. The degree of overlap between dyspepsia and IBS was determined.
Of 239 papers evaluated, 150 reported prevalence of dyspepsia and 19 (involving 18,173 subjects) reported the proportion of subjects with IBS within the same population. The prevalence of dyspepsia was 27% (95% CI, 23%-31%). The prevalence of IBS in subjects with dyspepsia was 37% (95% CI, 30%-45%) compared with 7% (95% CI, 5%-10%) in those without. The pooled OR for IBS in subjects with dyspepsia was 8 (95% CI, 5.74-11.16). The degree of overlap between the 2 conditions varied from 15% to 42%, depending on diagnostic criteria used for each.
Individuals with dyspepsia have an 8-fold increase in prevalence of IBS compared with the population. The strength of the association suggests common pathogenic mechanisms. Dyspeptic patients should be assessed routinely for IBS.
消化不良和肠易激综合征（IBS）是常见的病症，可在患者中同时存在。我们进行了系统综述和荟萃分析，以评估消化不良患者中 IBS 的患病率。
通过 MEDLINE 和 EMBASE 文献检索（23457 条引文），确定截至 2008 年 8 月发表的相关文章。合格的研究包括从社区、工作场所、献血或筛查诊所、家庭医生办公室或内科诊所招募的成年人。选择的研究报告了同一人群中消化不良和 IBS 的患病率。对所有研究进行了汇总，并比较了消化不良和无消化不良患者中 IBS 的患病率。计算了比值比（OR）和置信区间（CI）。确定了消化不良和 IBS 之间的重叠程度。
在评估的 239 篇论文中，有 150 篇报告了消化不良的患病率，有 19 篇（涉及 18173 名受试者）报告了同一人群中 IBS 患者的比例。消化不良的患病率为 27%（95%CI，23%-31%）。在有消化不良的患者中，IBS 的患病率为 37%（95%CI，30%-45%），而在无消化不良的患者中为 7%（95%CI，5%-10%）。消化不良患者中 IBS 的合并 OR 为 8（95%CI，5.74-11.16）。这两种疾病之间的重叠程度因每种疾病的诊断标准而异，从 15%到 42%不等。
与普通人群相比，患有消化不良的个体患 IBS 的患病率增加了 8 倍。这种关联的强度表明存在共同的发病机制。应常规评估消化不良患者是否患有 IBS。
