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本文引用的文献

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Genomic and genetic characterization of the bile stress response of probiotic Lactobacillus reuteri ATCC 55730.益生菌罗伊氏乳杆菌ATCC 55730胆汁应激反应的基因组和遗传特征分析
Appl Environ Microbiol. 2008 Mar;74(6):1812-9. doi: 10.1128/AEM.02259-07. Epub 2008 Feb 1.
2
Transcriptional responses of Enterococcus faecalis V583 to bovine bile and sodium dodecyl sulfate.粪肠球菌V583对牛胆汁和十二烷基硫酸钠的转录反应。
Appl Environ Microbiol. 2007 Sep;73(18):5767-74. doi: 10.1128/AEM.00651-07. Epub 2007 Jul 27.
3
Characterization of a novel bile-inducible operon encoding a two-component regulatory system in Lactobacillus acidophilus.嗜酸乳杆菌中一个编码双组分调节系统的新型胆汁诱导操纵子的特性分析。
J Bacteriol. 2007 Jul;189(13):4624-34. doi: 10.1128/JB.00337-07. Epub 2007 Apr 20.
4
Multidrug-resistance efflux pumps - not just for resistance.多药耐药性外排泵——不仅仅是为了耐药。
Nat Rev Microbiol. 2006 Aug;4(8):629-36. doi: 10.1038/nrmicro1464.
5
Transcriptional and functional analysis of oxalyl-coenzyme A (CoA) decarboxylase and formyl-CoA transferase genes from Lactobacillus acidophilus.嗜酸乳杆菌草酰辅酶A（CoA）脱羧酶和甲酰辅酶A转移酶基因的转录及功能分析
Appl Environ Microbiol. 2006 Mar;72(3):1891-9. doi: 10.1128/AEM.72.3.1891-1899.2006.
6
The Bifidobacterium longum NCIMB 702259T ctr gene codes for a novel cholate transporter.长双歧杆菌NCIMB 702259T的ctr基因编码一种新型胆酸盐转运蛋白。
Appl Environ Microbiol. 2006 Jan;72(1):923-6. doi: 10.1128/AEM.72.1.923-926.2006.
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Functional analysis of putative adhesion factors in Lactobacillus acidophilus NCFM.嗜酸乳杆菌NCFM中假定粘附因子的功能分析
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Microarray analysis of a two-component regulatory system involved in acid resistance and proteolytic activity in Lactobacillus acidophilus.嗜酸乳杆菌中参与耐酸性和蛋白水解活性的双组分调节系统的微阵列分析。
Appl Environ Microbiol. 2005 Oct;71(10):5794-804. doi: 10.1128/AEM.71.10.5794-5804.2005.
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Genomic features of lactic acid bacteria effecting bioprocessing and health.影响生物加工和健康的乳酸菌的基因组特征。
FEMS Microbiol Rev. 2005 Aug;29(3):393-409. doi: 10.1016/j.femsre.2005.04.007.
10
A PrfA-regulated bile exclusion system (BilE) is a novel virulence factor in Listeria monocytogenes.一种由PrfA调控的胆汁排除系统（BilE）是单核细胞增生李斯特菌中的一种新型毒力因子。
Mol Microbiol. 2005 Feb;55(4):1183-95. doi: 10.1111/j.1365-2958.2004.04454.x.

转运蛋白在嗜酸乳杆菌胆汁耐受性中的作用。

Role of transporter proteins in bile tolerance of Lactobacillus acidophilus.

作者信息

Pfeiler Erika A, Klaenhammer Todd R

机构信息

Genomic Sciences Graduate Program, Department of Food, Bioprocessing, & Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA.

出版信息

Appl Environ Microbiol. 2009 Sep;75(18):6013-6. doi: 10.1128/AEM.00495-09. Epub 2009 Jul 24.

DOI:10.1128/AEM.00495-09
PMID:19633113
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2747850/
Abstract

Lactobacillus acidophilus NCFM derivatives containing deletion mutations in the transporter genes LBA0552, LBA1429, LBA1446, and LBA1679 exhibited increased sensitivity to bile. These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential accumulations of ciprofloxacin and taurocholate.

摘要

在转运蛋白基因LBA0552、LBA1429、LBA1446和LBA1679中含有缺失突变的嗜酸乳杆菌NCFM衍生物对胆汁的敏感性增加。这些菌株对多种抑制性化合物表现出独特的敏感性模式，以及环丙沙星和牛磺胆酸盐的差异积累。