Pfeiler Erika A, Klaenhammer Todd R
Genomic Sciences Graduate Program, Department of Food, Bioprocessing, & Nutrition Sciences, North Carolina State University, Raleigh, NC 27695, USA.
Appl Environ Microbiol. 2009 Sep;75(18):6013-6. doi: 10.1128/AEM.00495-09. Epub 2009 Jul 24.
Lactobacillus acidophilus NCFM derivatives containing deletion mutations in the transporter genes LBA0552, LBA1429, LBA1446, and LBA1679 exhibited increased sensitivity to bile. These strains showed unique patterns of sensitivity to a variety of inhibitory compounds, as well as differential accumulations of ciprofloxacin and taurocholate.
在转运蛋白基因LBA0552、LBA1429、LBA1446和LBA1679中含有缺失突变的嗜酸乳杆菌NCFM衍生物对胆汁的敏感性增加。这些菌株对多种抑制性化合物表现出独特的敏感性模式,以及环丙沙星和牛磺胆酸盐的差异积累。