• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

The licensing checkpoint opens up.

作者信息

Ge Xin Quan, Blow J Julian

机构信息

University of Dundee, Dundee, UK.

出版信息

Cell Cycle. 2009 Aug;8(15):2320-2. Epub 2009 Aug 1.

PMID:19633410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2896791/
Abstract
摘要

相似文献

1
The licensing checkpoint opens up.许可检查点开启。
Cell Cycle. 2009 Aug;8(15):2320-2. Epub 2009 Aug 1.
2
The origin of CDK regulation.细胞周期蛋白依赖性激酶(CDK)调控的起源。
Nat Cell Biol. 2001 Aug;3(8):E182-4. doi: 10.1038/35087119.
3
Triggering ubiquitination of a CDK inhibitor at origins of DNA replication.在DNA复制起点触发细胞周期蛋白依赖性激酶抑制剂的泛素化。
Nat Cell Biol. 2001 Aug;3(8):715-22. doi: 10.1038/35087026.
4
Replication licensing and the DNA damage checkpoint.复制许可与DNA损伤检查点。
Front Biosci (Landmark Ed). 2009 Jun 1;14(13):5013-30. doi: 10.2741/3584.
5
p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest.p21(Cip1)和p27(Kip1)调节缺氧应激后的细胞周期重新进入,但对于缺氧诱导的停滞并非必需。
Mol Cell Biol. 2001 Feb;21(4):1196-206. doi: 10.1128/MCB.21.4.1196-1206.2001.
6
Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27.Myc 通过激活 Cdk1 和磷酸化 p27 来刺激细胞周期进程。
Sci Rep. 2019 Dec 10;9(1):18693. doi: 10.1038/s41598-019-54917-1.
7
[Regulation of the cell cycle--involvement of protein inhibitors of cyclin-dependent kinases].细胞周期的调控——细胞周期蛋白依赖性激酶的蛋白抑制剂的作用
Postepy Biochem. 1995;41(2):80-93.
8
Activation of cyclin D1-kinase in murine fibroblasts lacking both p21(Cip1) and p27(Kip1).在同时缺乏p21(Cip1)和p27(Kip1)的小鼠成纤维细胞中细胞周期蛋白D1激酶的激活
Oncogene. 2002 Nov 21;21(53):8067-74. doi: 10.1038/sj.onc.1206019.
9
New roles for p21 and p27 cell-cycle inhibitors: a function for each cell compartment?p21和p27细胞周期抑制剂的新作用:每个细胞区室都有其功能?
Trends Cell Biol. 2003 Feb;13(2):65-70. doi: 10.1016/s0962-8924(02)00043-0.
10
Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-beta.Kip/Cip和Ink4细胞周期蛋白依赖性激酶抑制剂协同作用,以响应转化生长因子-β诱导细胞周期停滞。
Genes Dev. 1995 Aug 1;9(15):1831-45. doi: 10.1101/gad.9.15.1831.

引用本文的文献

1
Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics.通过CDK4/6-RB信号通路和化学遗传学对人类DNA复制许可进行时间控制。
Nat Commun. 2025 Sep 12;16(1):8268. doi: 10.1038/s41467-025-63669-8.
2
A high-throughput screening identifies MCM chromatin loading inhibitors targeting cells with increased replication origins.一项高通量筛选鉴定出了靶向具有增加的复制起点的细胞的MCM染色质加载抑制剂。
iScience. 2024 Jul 22;27(8):110567. doi: 10.1016/j.isci.2024.110567. eCollection 2024 Aug 16.
3
Quantity and quality of minichromosome maintenance protein complexes couple replication licensing to genome integrity.微染色体维持蛋白复合物的数量和质量将复制许可与基因组完整性联系起来。
Commun Biol. 2024 Feb 9;7(1):167. doi: 10.1038/s42003-024-05855-w.
4
Clinical significances of p27 in digestive tract cancers: a comprehensive analysis on immunohistochemistry staining, published literatures, microarray and RNA-seq data.p27在消化道癌症中的临床意义:对免疫组织化学染色、已发表文献、基因芯片和RNA测序数据的综合分析
Oncotarget. 2018 Jan 23;9(15):12284-12303. doi: 10.18632/oncotarget.24316. eCollection 2018 Feb 23.
5
Rapid DNA replication origin licensing protects stem cell pluripotency.快速的 DNA 复制起始许可保护干细胞的多能性。
Elife. 2017 Nov 17;6:e30473. doi: 10.7554/eLife.30473.
6
Deficiency in origin licensing proteins impairs cilia formation: implications for the aetiology of Meier-Gorlin syndrome.起源许可蛋白缺失会损害纤毛形成:对 Meier-Gorlin 综合征发病机制的影响。
PLoS Genet. 2013;9(3):e1003360. doi: 10.1371/journal.pgen.1003360. Epub 2013 Mar 14.
7
Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress.起源许可能力的降低会使肿瘤细胞特别容易受到复制应激的影响。
Mol Cancer Res. 2013 Apr;11(4):370-80. doi: 10.1158/1541-7786.MCR-12-0491. Epub 2013 Jan 30.
8
Mechanisms and pathways of growth failure in primordial dwarfism.原基性侏儒症生长障碍的机制和途径。
Genes Dev. 2011 Oct 1;25(19):2011-24. doi: 10.1101/gad.169037.
9
A reduction of licensed origins reveals strain-specific replication dynamics in mice.许可起源的减少揭示了小鼠中菌株特异性的复制动态。
Mamm Genome. 2011 Oct;22(9-10):506-17. doi: 10.1007/s00335-011-9333-7. Epub 2011 May 25.
10
Understanding the limitations of radiation-induced cell cycle checkpoints.理解辐射诱导的细胞周期检查点的局限性。
Crit Rev Biochem Mol Biol. 2011 Aug;46(4):271-83. doi: 10.3109/10409238.2011.575764. Epub 2011 Apr 27.

本文引用的文献

1
Origin licensing and p53 status regulate Cdk2 activity during G(1).起始许可和p53状态在G1期调节Cdk2活性。
Cell Cycle. 2009 Jun 15;8(12):1952-63. doi: 10.4161/cc.8.12.8811. Epub 2009 Jun 21.
2
Replication licensing promotes cyclin D1 expression and G1 progression in untransformed human cells.复制许可促进未转化人类细胞中的细胞周期蛋白D1表达和G1期进程。
Cell Cycle. 2009 Jan 1;8(1):125-36. doi: 10.4161/cc.8.1.7528.
3
Replication licensing and cancer--a fatal entanglement?复制许可与癌症——致命的纠缠?
Nat Rev Cancer. 2008 Oct;8(10):799-806. doi: 10.1038/nrc2500. Epub 2008 Aug 29.
4
Reduced Mcm2 expression results in severe stem/progenitor cell deficiency and cancer.Mcm2表达降低会导致严重的干细胞/祖细胞缺陷和癌症。
Stem Cells. 2007 Dec;25(12):3121-32. doi: 10.1634/stemcells.2007-0483. Epub 2007 Aug 23.
5
Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells.众志成城:真核细胞中通过多种机制防止再复制
Genes Dev. 2007 Mar 1;21(5):497-518. doi: 10.1101/gad.1508907.
6
A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice.Mcm4的一个有活性的等位基因会导致小鼠染色体不稳定和乳腺腺癌。
Nat Genet. 2007 Jan;39(1):93-8. doi: 10.1038/ng1936. Epub 2006 Dec 3.
7
Proliferating human cells hypomorphic for origin recognition complex 2 and pre-replicative complex formation have a defect in p53 activation and Cdk2 kinase activation.对于起源识别复合物2和复制前复合物形成呈亚等位基因不足的增殖人类细胞,在p53激活和Cdk2激酶激活方面存在缺陷。
J Biol Chem. 2006 Mar 10;281(10):6253-60. doi: 10.1074/jbc.M507150200. Epub 2006 Jan 10.
8
Acute reduction of an origin recognition complex (ORC) subunit in human cells reveals a requirement of ORC for Cdk2 activation.在人类细胞中急性降低一种复制起始识别复合体(ORC)亚基,揭示了ORC对细胞周期蛋白依赖性激酶2(Cdk2)激活的必要性。
J Biol Chem. 2005 Jul 29;280(30):27624-30. doi: 10.1074/jbc.M502615200. Epub 2005 Jun 7.
9
Preventing re-replication of chromosomal DNA.防止染色体DNA的再复制。
Nat Rev Mol Cell Biol. 2005 Jun;6(6):476-86. doi: 10.1038/nrm1663.
10
Inhibiting the expression of DNA replication-initiation proteins induces apoptosis in human cancer cells.抑制DNA复制起始蛋白的表达可诱导人癌细胞凋亡。
Cancer Res. 2003 Nov 1;63(21):7356-64.