Miyagi Satoru, Kato Hidemasa, Okuda Akihiko
Department of Cellular and Molecular Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan.
Cell Mol Life Sci. 2009 Dec;66(23):3675-84. doi: 10.1007/s00018-009-0097-0. Epub 2009 Jul 25.
SoxB1 factors, which include Sox1, 2, and 3, share more than 90% amino acid identity in their DNA binding HMG box and participate in diverse developmental events. They are known to exert cell-type-specific functions in concert with other transcription factors on Sox factor-dependent regulatory enhancers. Due to the high degree of sequence similarity both within and outside the HMG box, SoxB1 members show almost identical biological activities. As a result, they exhibit strong functional redundancy in regions where SoxB1 members are coexpressed, such as neural stem/progenitor cells in the developing central nervous system.
SoxB1因子包括Sox1、2和3，它们在DNA结合HMG框中具有超过90%的氨基酸同一性，并参与多种发育事件。已知它们与其他转录因子协同作用于Sox因子依赖性调控增强子，发挥细胞类型特异性功能。由于HMG框内外的序列相似性很高，SoxB1成员表现出几乎相同的生物学活性。因此，它们在SoxB1成员共表达的区域，如发育中的中枢神经系统中的神经干/祖细胞，表现出很强的功能冗余性。
