在阴道炎模型中阿巴康唑对白色念珠菌的疗效。
Efficacy of albaconazole against Candida albicans in a vaginitis model.
作者信息
González Gloria M, Robledo Efrén, Garza-González Elvira, Elizondo Mariana, González J Gerardo
机构信息
Departamento de Microbiología, Facultad de Medicina, Universidad Autónoma de Nuevo León, Monterrey, Nuevo León, México.
出版信息
Antimicrob Agents Chemother. 2009 Oct;53(10):4540-1. doi: 10.1128/AAC.00565-09. Epub 2009 Jul 27.
Abstract
The efficacy of albaconazole (ABC) was evaluated using a murine model of vaginal Candida albicans infection. Both ABC and fluconazole (FLC) were effective in reducing the fungal load from vaginas of infected mice; however, ABC demonstrated encouraging activities against an FLC-resistant strain, with trends toward superiority over FLC in some treatment groups.
摘要
使用白色念珠菌阴道感染小鼠模型评估了阿巴康唑（ABC）的疗效。ABC和氟康唑（FLC）均可有效降低感染小鼠阴道中的真菌载量；然而，ABC对氟康唑耐药菌株表现出令人鼓舞的活性，在某些治疗组中显示出优于氟康唑的趋势。
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