Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Neuroimage. 2010 Jan 1;49(1):561-7. doi: 10.1016/j.neuroimage.2009.07.033. Epub 2009 Jul 28.
We describe a neuroimaging protocol that utilizes an anatomical atlas of the human head to guide diffuse optical tomography of human brain activation. The protocol is demonstrated by imaging the hemodynamic response to median-nerve stimulation in three healthy subjects, and comparing the images obtained using a head atlas with the images obtained using the subject-specific head anatomy. The results indicate that using the head atlas anatomy it is possible to reconstruct the location of the brain activation to the expected gyrus of the brain, in agreement with the results obtained with the subject-specific head anatomy. The benefits of this novel method derive from eliminating the need for subject-specific head anatomy and thus obviating the need for a subject-specific MRI to improve the anatomical interpretation of diffuse optical tomography images of brain activation.
我们描述了一种利用人类头部解剖图谱指导人类大脑激活弥散光学断层扫描的神经影像学方法。该方案通过对 3 名健康受试者的正中神经刺激后的血流动力学反应进行成像，并将使用头部图谱获得的图像与使用受试者特定头部解剖结构获得的图像进行比较，从而得到了验证。结果表明，使用头部图谱解剖结构可以将大脑激活的位置重建到预期的大脑脑回，这与使用受试者特定头部解剖结构获得的结果一致。这种新方法的优点在于消除了对受试者特定头部解剖结构的需求，从而避免了使用受试者特定的 MRI 来改善大脑激活弥散光学断层扫描图像的解剖学解释的需要。
