Wasilewski Michał, Scorrano Luca
Dulbecco-Telethon Institute, Venetian Institute of Molecular Medicine, 35129 Padova, Italy.
Trends Endocrinol Metab. 2009 Aug;20(6):287-94. doi: 10.1016/j.tem.2009.03.007. Epub 2009 Jul 31.
Mitochondria are key organelles in conversion of energy, regulation of cellular signaling and amplification of programmed cell death. The anatomy of the organelle matches this functional versatility in complexity and is modulated by the concerted action of proteins that impinge on its fusion-fission equilibrium. A growing body of evidence implicates changes in mitochondrial shape in the progression of apoptosis and, therefore, proteins governing such changes are likely candidates for involvement in pathogenetic mechanisms in neurodegeneration and cancer. Here, we discuss the recent advancements in our knowledge about the machinery that regulates mitochondrial shape and on the role of molecular mechanisms controlling mitochondrial morphology during cell death.
线粒体是能量转换、细胞信号调节和程序性细胞死亡放大过程中的关键细胞器。该细胞器的结构在复杂性上与这种功能多样性相匹配，并受到影响其融合-分裂平衡的蛋白质协同作用的调节。越来越多的证据表明线粒体形态的变化与细胞凋亡的进程有关，因此，控制这种变化的蛋白质很可能参与神经退行性疾病和癌症的发病机制。在这里，我们讨论了我们在调节线粒体形态的机制以及细胞死亡过程中控制线粒体形态的分子机制的作用方面的最新知识进展。
