Desmet Tim, Morent Rino, De Geyter Nathalie, Leys Christophe, Schacht Etienne, Dubruel Peter
Polymer Chemistry & Biomaterials Research Group, Ghent University, Krijgslaan 281 S4 Bis, Ghent, 9000, Belgium.
Biomacromolecules. 2009 Sep 14;10(9):2351-78. doi: 10.1021/bm900186s.
In modern technology, there is a constant need to solve very complex problems and to fine-tune existing solutions. This is definitely the case in modern medicine with emerging fields such as regenerative medicine and tissue engineering. The problems, which are studied in these fields, set very high demands on the applied materials. In most cases, it is impossible to find a single material that meets all demands such as biocompatibility, mechanical strength, biodegradability (if required), and promotion of cell-adhesion, proliferation, and differentiation. A common strategy to circumvent this problem is the application of composite materials, which combine the properties of the different constituents. Another possible strategy is to selectively modify the surface of a material using different modification techniques. In the past decade, the use of nonthermal plasmas for selective surface modification has been a rapidly growing research field. This will be the highlight of this review. In a first part of this paper, a general introduction in the field of surface engineering will be given. Thereafter, we will focus on plasma-based strategies for surface modification. The purpose of the present review is twofold. First, we wish to provide a tutorial-type review that allows a fast introduction for researchers into the field. Second, we aim to give a comprehensive overview of recent work on surface modification of polymeric biomaterials, with a focus on plasma-based strategies. Some recent trends will be exemplified. On the basis of this literature study, we will conclude with some future trends for research.
在现代技术领域，始终需要解决非常复杂的问题并对现有解决方案进行微调。在现代医学中，再生医学和组织工程等新兴领域无疑也是如此。这些领域所研究的问题对应用材料提出了极高的要求。在大多数情况下，不可能找到一种能满足所有要求的单一材料，比如生物相容性、机械强度、生物可降解性（如果需要的话）以及促进细胞黏附、增殖和分化。规避这一问题的常见策略是应用复合材料，复合材料结合了不同成分的特性。另一种可能的策略是使用不同的改性技术对材料表面进行选择性改性。在过去十年中，利用非热等离子体进行选择性表面改性一直是一个快速发展的研究领域。这将是本综述的重点。在本文的第一部分，将对表面工程领域进行一般性介绍。此后，我们将聚焦于基于等离子体的表面改性策略。本综述的目的有两个。其一，我们希望提供一篇教程式综述，以便研究人员能快速进入该领域。其二，我们旨在全面概述聚合物生物材料表面改性的近期研究工作，重点是基于等离子体的策略。将举例说明一些近期趋势。基于这项文献研究，我们将以一些未来的研究趋势作为总结。
