Electronic Materials Research Laboratory, School of Engineering and Physical Sciences, James Cook University, Townsville, Queensland, Australia.
Acta Biomater. 2011 May;7(5):2015-28. doi: 10.1016/j.actbio.2010.12.024. Epub 2010 Dec 29.
Despite many synthetic biomaterials having physical properties that are comparable or even superior to those of natural body tissues, they frequently fail due to the adverse physiological reactions they cause within the human body, such as infection and inflammation. The surface modification of biomaterials is an economical and effective method by which biocompatibility and biofunctionality can be achieved while preserving the favorable bulk characteristics of the biomaterial, such as strength and inertness. Amongst the numerous surface modification techniques available, plasma surface modification affords device manufacturers a flexible and environmentally friendly process that enables tailoring of the surface morphology, structure, composition, and properties of the material to a specific need. There are a vast range of possible applications of plasma modification in biomaterial applications, however, the focus of this review paper is on processes that can be used to develop surface morphologies and chemical structures for the prevention of adhesion and proliferation of pathogenic bacteria on the surfaces of in-dwelling medical devices. As such, the fundamental principles of bacterial cell attachment and biofilm formation are also discussed. Functional organic plasma polymerised coatings are also discussed for their potential as biosensitive interfaces, connecting inorganic/metallic electronic devices with their physiological environments.
尽管许多合成生物材料具有可与天然体组织相媲美的物理特性，甚至更优，但它们常常因在人体内引起的不良反应而失效，如感染和炎症。生物材料的表面改性是一种经济有效的方法，可以在保持生物材料的有利整体特性（如强度和惰性）的同时，实现生物相容性和生物功能性。在众多可用的表面改性技术中，等离子体表面改性为设备制造商提供了一种灵活且环保的工艺，可根据特定需求对材料的表面形态、结构、组成和性能进行定制。等离子体改性在生物材料应用中有广泛的可能应用，但本文的重点是可用于开发表面形态和化学结构的处理方法，以防止驻留式医疗设备表面上的致病性细菌的黏附和增殖。因此，还讨论了细菌细胞附着和生物膜形成的基本原理。还讨论了功能性有机等离子体聚合涂层作为生物敏感界面的潜力，将无机/金属电子设备与其生理环境连接起来。
