Valentín A, Humphrey J D
Department of Biomedical Engineering, 337 Zachry Engineering Center, 3120 TAMU, Texas A&M University, College Station, TX 77843-3120, USA.
Philos Trans A Math Phys Eng Sci. 2009 Sep 13;367(1902):3585-606. doi: 10.1098/rsta.2009.0113.
Evolving constituent composition and organization are important determinants of the biomechanical behaviour of soft tissues. In arteries, vascular smooth muscle cells and fibroblasts continually produce and degrade matrix constituents in preferred modes and at altered rates in response to changing mechanical stimuli. Smooth muscle cells similarly exhibit vasoactive changes that contribute to the control of overall structure, function and mechanical behaviour. Constrained mixture models provide a useful framework in which to quantify arterial growth and remodelling for they can account for cell-mediated changes in individual structurally significant constituents. Our simulations show that the combined effects of changing mass density turnover and vasoactivity, as well as the prestretch at which constituents are incorporated within extant matrix, are essential to capture salient features of bounded arterial growth and remodelling. These findings emphasize the importance of formulating biologically motivated constitutive relations in any theory of growth and remodelling and distinct advantages of the constrained mixture approach, in particular.
不断演变的成分组成和组织结构是软组织生物力学行为的重要决定因素。在动脉中，血管平滑肌细胞和成纤维细胞会根据不断变化的机械刺激，以特定模式并以变化的速率持续产生和降解基质成分。平滑肌细胞同样会表现出血管活性变化，这有助于控制整体结构、功能和机械行为。约束混合模型提供了一个有用的框架，用于量化动脉生长和重塑，因为它们可以解释细胞介导的个体结构重要成分的变化。我们的模拟表明，质量密度周转和血管活性变化的综合影响，以及成分在现有基质中嵌入时的预拉伸，对于捕捉有界动脉生长和重塑的显著特征至关重要。这些发现强调了在任何生长和重塑理论中制定具有生物学动机的本构关系的重要性，特别是约束混合方法的独特优势。
