Perera Tharangani R W, Skerrett-Byrne David A, Gibb Zamira, Nixon Brett, Swegen Aleona
Priority Research Centre for Reproductive Science, College of Engineering, Science and Environment, University of Newcastle, Callaghan, NSW 2308, Australia.
Animals (Basel). 2022 Aug 26;12(17):2194. doi: 10.3390/ani12172194.
New biomarkers promise to transform veterinary practice through rapid diagnosis of diseases, effective monitoring of animal health and improved welfare and production efficiency. However, the road from biomarker discovery to translation is not always straightforward. This review focuses on molecular biomarkers under development in the veterinary field, introduces the emerging technological approaches transforming this space and the role of 'omics platforms in novel biomarker discovery. The vast majority of veterinary biomarkers are at preliminary stages of development and not yet ready to be deployed into clinical translation. Hence, we examine the major challenges encountered in the process of biomarker development from discovery, through validation and translation to clinical practice, including the hurdles specific to veterinary practice and to each of the 'omics platforms-transcriptomics, proteomics, lipidomics and metabolomics. Finally, recommendations are made for the planning and execution of biomarker studies with a view to assisting the success of novel biomarkers in reaching their full potential.
新的生物标志物有望通过疾病的快速诊断、动物健康的有效监测以及改善福利和生产效率来变革兽医实践。然而，从生物标志物发现到转化应用的道路并非总是一帆风顺。本综述聚焦于兽医领域正在研发的分子生物标志物，介绍正在改变这一领域的新兴技术方法以及“组学”平台在新型生物标志物发现中的作用。绝大多数兽医生物标志物仍处于研发的初步阶段，尚未准备好应用于临床转化。因此，我们审视了生物标志物从发现到验证、再到转化应用于临床实践过程中遇到的主要挑战，包括兽医实践以及每个“组学”平台（转录组学、蛋白质组学、脂质组学和代谢组学）所特有的障碍。最后，针对生物标志物研究的规划和实施提出了建议，以期助力新型生物标志物充分发挥其潜力并取得成功。
