从CDC26-APC6结构洞察后期促进复合物TPR亚结构域组装
Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure.
作者信息
Wang Jing, Dye Billy T, Rajashankar Kanagalaghatta R, Kurinov Igor, Schulman Brenda A
机构信息
Departments of Structural Biology and Genetics/Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
出版信息
Nat Struct Mol Biol. 2009 Sep;16(9):987-9. doi: 10.1038/nsmb.1645. Epub 2009 Aug 9.
The multisubunit anaphase promoting complex (APC) is an essential cell-cycle regulator. Although CDC26 is known to have a role in APC assembly, its molecular function has remained unclear. Biophysical, structural and genetic studies presented here reveal that CDC26 stabilizes the structure of APC6, a core TPR protein required for APC integrity. Notably, CDC26-APC6 association involves an intermolecular TPR mimic composed of one helix from each protein.
多亚基后期促进复合物（APC）是一种重要的细胞周期调节因子。虽然已知CDC26在APC组装中发挥作用，但其分子功能仍不清楚。本文所展示的生物物理、结构和遗传学研究表明，CDC26可稳定APC6的结构，APC6是APC完整性所需的核心TPR蛋白。值得注意的是，CDC26与APC6的结合涉及一种分子间TPR模拟物，该模拟物由每种蛋白质的一个螺旋组成。
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